Effect of high lipid and allopurinol on the development of experimentally induced arthritis in rats

Abstract EN

Male albino rats were fed a high lipid diet for 5 consecutive weeks.

We studied the development of paw inflammation after an injection with Freund’s complete adjuvant.

Increasing the lipid content of the diet significantly increased the rate ofpaw inflammation .

Also the effect of oral administration of xanthine oxidase inhibitor (allopur'mol 50 mg /kg) for 15 consecutive days on this process was studied.

Results indicated that injlammation was significantly inhibited by allopurinol.