Spectrophotometric determination of some analgesic drugs in pharmaceutical formulations using n-bromosuccinimide as an oxidant
Joint Authors
al-Didamuni, Akram M.
Sad, Munir Z.
Salim, Nura O.
Source
Arab Journal of Basic and Applied Sciences
Issue
Vol. 17, Issue 0 (30 Apr. 2015), pp.43-50, 8 p.
Publisher
University of Bahrain College of Science
Publication Date
2015-04-30
Country of Publication
Bahrain
No. of Pages
8
Main Subjects
Topics
Abstract EN
New sensitive and rapid spectrophotometric methods for the determination of four analgesic drugs namely, nalbuphine (NALB), naltrexone (NALT), morphine (MORF) and tramadol (TRAM) in pharmaceutical formulations were developed and optimized.
The proposed methods involve the addition of a measured excess of N-bromosuccinimide in acid medium followed by determination of unreacted NBS by reacting with either a fixed amount of methyl orange and measuring the absorbance at 508 nm (Method A), or orange G and measuring the absorbance at 478 nm (Method B).
In both methods, the amount of NBS reacted corresponds to the amount of drugs.
Under the optimum conditions, Beer’s law limit, molar absorptivity and Sandell’s sensitivity were calculated.
The limits of detection and quantification were also reported for both methods.
Statistical evaluation of the methods was examined by determining intra-day and inter-day precisions.
The methods were successfully applied to the assay of drugs in their pharmaceutical formulations.
No interference was observed from common additives and the validity of the methods was tested.
American Psychological Association (APA)
al-Didamuni, Akram M.& Sad, Munir Z.& Salim, Nura O.. 2015. Spectrophotometric determination of some analgesic drugs in pharmaceutical formulations using n-bromosuccinimide as an oxidant. Arab Journal of Basic and Applied Sciences،Vol. 17, no. 0, pp.43-50.
https://search.emarefa.net/detail/BIM-535268
Modern Language Association (MLA)
al-Didamuni, Akram M.…[et al.]. Spectrophotometric determination of some analgesic drugs in pharmaceutical formulations using n-bromosuccinimide as an oxidant. Arab Journal of Basic and Applied Sciences Vol. 17 (Apr. 2015), pp.43-50.
https://search.emarefa.net/detail/BIM-535268
American Medical Association (AMA)
al-Didamuni, Akram M.& Sad, Munir Z.& Salim, Nura O.. Spectrophotometric determination of some analgesic drugs in pharmaceutical formulations using n-bromosuccinimide as an oxidant. Arab Journal of Basic and Applied Sciences. 2015. Vol. 17, no. 0, pp.43-50.
https://search.emarefa.net/detail/BIM-535268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 49-50
Record ID
BIM-535268