HLA antigens, sicam-1, INF-y and hepatitis C virus antibodies in lichen planus
Other Title(s)
مستضدات التوافق النسيجي و قياس جزئ الالتصاق الخلوي الذائب-1 و الأنترفيرون-جاما و الأجسام المضادة لفيروس الالتهاب الكبدي سي في المصل في مرضى الحزاز المنبسط
Joint Authors
al-Mubashir, Ala al-Din Abd
Abd al-Latif, Hanan Harith
Abd al-Hafiz, Kamal al-Din
Ata Allah, Dalia Abd al-Aziz
Source
Issue
Vol. 27, Issue 3 (30 Sep. 2003), pp.21-34, 14 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2003-09-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Fifty one patients with lichen planus (LP)were studied for human Leucocyte antigens.
(HLA) (class I & II) by micro lymphocyto toxicity assay, serum levels of soluble Intercellular Adhesion Molecule-1 (sICAM) and Interferon (IFN- y) by Enzyme linked Immuno-Sorbent Assay (ELISA) and by Enzyme Amplified Sensitivity mmunoassay(EASIA) respectively, and the detection of Hepatitis C- virus (HCV)anti bodies by Axsym.
(ABBOTT laboratories) Seventy two healthy unrelated individuals were studied as control group.
There were significant increased frequencies of HLA-A19, B5, CW5, CW7, DR1, and DQ3; a significant decreased frequencies of HLA-CW3, DR4, DQ1 were found in patients in comparison to controls.
When patients with mucous membrane affection were compared to controls, there were increased frequencies ofHLA-A19, B5, CW3, CW7, CW17, DR1 and DQ3.
Patients without mucous membrane affection showed increased frequencies ofB5, CW5, CW7, DR1, DR9, DQ3 and decreased frequencies of HLA-DR4 and DQ1 in comparison to controls.
No significant differences were found when patients with mucous membrane affection were compared to those without mucous membrane affection.
No significant differences were also noticed when the clinical types actinic, classic and hypertrophic LP were compared to each other.
Sero-positive HCV patients represented 31.4% of the studied LP patients with significant increased frequencies of HLA-B5, CW5, CW7, DR1, DR9 and DQ3 in comparison to controls.
Sero-negative HCV patients showed increasedfrequencies of HLA-B5, CW5, CW7, CW17, DR1, and DQ3 and significant decreased frequencies of HLA- DR4 and DQ2.
No significant differences were found in HLA antigens between Sero-positive and Sero-negative HCV patients.
HLA-DR1 was found in 90 % of patients.
This represented a striking statistically significant result in the present study.
No significant differences were noticed in serum levels of sICAM-1 and IFN-y in patients when compared to controls and when the clinical subgroups were compared to each other.
There was no correlation between slCAM and IFN-y in the studied patients.
The findings of the present study strongly suggest that a genetic predisposition or susceptibility play a role to some extent in the development of LP.
American Psychological Association (APA)
Abd al-Latif, Hanan Harith& al-Mubashir, Ala al-Din Abd& Abd al-Hafiz, Kamal al-Din& Ata Allah, Dalia Abd al-Aziz. 2003. HLA antigens, sicam-1, INF-y and hepatitis C virus antibodies in lichen planus. Assiut Medical Journal،Vol. 27, no. 3, pp.21-34.
https://search.emarefa.net/detail/BIM-53539
Modern Language Association (MLA)
Abd al-Latif, Hanan Harith…[et al.]. HLA antigens, sicam-1, INF-y and hepatitis C virus antibodies in lichen planus. Assiut Medical Journal Vol. 27, no. 3 (Sep. 2003), pp.21-34.
https://search.emarefa.net/detail/BIM-53539
American Medical Association (AMA)
Abd al-Latif, Hanan Harith& al-Mubashir, Ala al-Din Abd& Abd al-Hafiz, Kamal al-Din& Ata Allah, Dalia Abd al-Aziz. HLA antigens, sicam-1, INF-y and hepatitis C virus antibodies in lichen planus. Assiut Medical Journal. 2003. Vol. 27, no. 3, pp.21-34.
https://search.emarefa.net/detail/BIM-53539
Data Type
Journal Articles
Language
English
Notes
Text in English, abstracts in Arabic & English
Record ID
BIM-53539