Immunodominant semen proteins III: IgG1 and IgG4 linkage in female immune infertility
Joint Authors
Brazdova, Andrea
Zidkova, Jarmila
Peltre, Gabriel
Ulcova Gallova, Zdena
Senechal, Helene
Kaveri, Srinivas
Poncet, Pascal
Source
Jordan Journal of Biological Sciences
Issue
Vol. 8, Issue 1 (31 Mar. 2015), pp.17-21, 5 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2015-03-31
Country of Publication
Jordan
No. of Pages
5
Main Subjects
Topics
Abstract EN
Active immune mechanism in the female reproductive tract may produce high levels of anti-seminal/sperm antibodies.
Generated antibodies in the process of isoimmunization seem to be associated with female immune infertility.
The aim of our study consists in the profiling of specific serum immunoglobulin classes and subclasses in infertile women.
We focus on the distribution of serum seminal/sperm-specific antibodies in order to find those apparently related to female isoimmunization.
Immunoglobulins G1-4, A1,2, M and E were measured by ELISA in serum from 30 infertile and 10 fertile females.
Anti-seminal/sperm IgG1 and IgG4 fractions were predominantly detected.
Anti-seminal IgG1 and IgG4 were observed approximately in the 2:1 ratio, anti-sperm fraction in the 1:2 ratio.
Strikingly, the approximate ratio between IgG1 and IgG2 was 3:1 in seminal specific and 2:1 in sperm specific antibodies.
Surprisingly, IgG3 antibodies were nearly negative for both antigen fractions, seminal and sperm.
Concerning our results, the proportionality does exist between seminal and sperm antibody fractions.
Based on the poorly detectable levels of semen specific IgE, M, A1,2, G3, the markers of pathologic female isoimmunization appear to be the serum IgG1 and IgG4.
These preliminary findings may contribute to a detailed patient diagnosis and an improved therapy.
American Psychological Association (APA)
Brazdova, Andrea& Senechal, Helene& Peltre, Gabriel& Zidkova, Jarmila& Ulcova Gallova, Zdena& Kaveri, Srinivas…[et al.]. 2015. Immunodominant semen proteins III: IgG1 and IgG4 linkage in female immune infertility. Jordan Journal of Biological Sciences،Vol. 8, no. 1, pp.17-21.
https://search.emarefa.net/detail/BIM-535409
Modern Language Association (MLA)
Brazdova, Andrea…[et al.]. Immunodominant semen proteins III: IgG1 and IgG4 linkage in female immune infertility. Jordan Journal of Biological Sciences Vol. 8, no. 1 (Mar. 2015), pp.17-21.
https://search.emarefa.net/detail/BIM-535409
American Medical Association (AMA)
Brazdova, Andrea& Senechal, Helene& Peltre, Gabriel& Zidkova, Jarmila& Ulcova Gallova, Zdena& Kaveri, Srinivas…[et al.]. Immunodominant semen proteins III: IgG1 and IgG4 linkage in female immune infertility. Jordan Journal of Biological Sciences. 2015. Vol. 8, no. 1, pp.17-21.
https://search.emarefa.net/detail/BIM-535409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 20-21
Record ID
BIM-535409