Plasma level of transforming growth factor β 1 in children with autism spectrum disorder
Joint Authors
Darwish, Muhammad
al-Jawhari, Tariq Muhammad
Abd al-Aziz, Nahhal
Sadaa, Ibtihal Shukayri
Source
Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Issue
Vol. 16, Issue 1 (30 Apr. 2015), pp.69-73, 5 p.
Publisher
Egyptian Society of Ear Nose Throat and Allied Science
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders characterized by pervasive abnormalities in social interaction and communication, and repetitive and restricted behavioral patterns and interests.
ASD include autistic disorder, Asperger’s disorder, pervasive developmental disorder not otherwise specific and childhood disintegrative disorders.
Objectives : To detect plasma level of transforming growth factor beta 1 (TGFbl) in children with ASD and to find out correlation between the plasma level of TGFb1 and severity of ASD.
Patients and methods : Our study included 30 patients with autistic spectrum disorder (ASD) diagnosed on the basis of criteria of autistic spectrum disorders as defined in Diagnostic and Statistical Manual of Mental Disorders fourth edition text revised (DSM-IV) (TR).
They were 26 males and 4 females, their ages ranged from 3 years to 13 years.
Thirty apparently healthy sex and age matched children served as controls (22 males and 8 females).
They were subjected to full history taking, clinical examination and severity rating using Child Autistic Rating Scale of Children (CARS) and Diagnostic and Statistical Manual of Mental Disorders fourth edition text revised (DSM-IV) (TR).
Results : Our study revealed : (a) sex distribution among the patient group with male / female ratio 6.5:1 ; (b) mean value of maternal age was significantly higher among patients than controls ; (c) about 50 % of patients had a history of prenatal complication ; (d) the patient group shows lower plasma level of TGFb1 compared to the control group.
Conclusion : There may be an important role for the immune system in autism spectrum disorders that may have profound implications for diagnosis and treatment of this disorder.
A negative correlation was found between severities of ASD and TGFb1 plasma level.
American Psychological Association (APA)
al-Jawhari, Tariq Muhammad& Abd al-Aziz, Nahhal& Darwish, Muhammad& Sadaa, Ibtihal Shukayri. 2015. Plasma level of transforming growth factor β 1 in children with autism spectrum disorder. Egyptian Journal of Ear, Nose, Throat and Allied Sciences،Vol. 16, no. 1, pp.69-73.
https://search.emarefa.net/detail/BIM-536342
Modern Language Association (MLA)
al-Jawhari, Tariq Muhammad…[et al.]. Plasma level of transforming growth factor β 1 in children with autism spectrum disorder. Egyptian Journal of Ear, Nose, Throat and Allied Sciences Vol. 16, no. 1 (2015), pp.69-73.
https://search.emarefa.net/detail/BIM-536342
American Medical Association (AMA)
al-Jawhari, Tariq Muhammad& Abd al-Aziz, Nahhal& Darwish, Muhammad& Sadaa, Ibtihal Shukayri. Plasma level of transforming growth factor β 1 in children with autism spectrum disorder. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2015. Vol. 16, no. 1, pp.69-73.
https://search.emarefa.net/detail/BIM-536342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 72-73
Record ID
BIM-536342