Antibiotic resistance pattern among aerobic gram negative bacilli isolated from patients in intensive care units

Abstract EN

To study the antimicrobial resistance pattern of aerobic Gram-negative bacilli isolated from patients in intensive care units in Hamad Medical Corporation, 108 non-dupli¬cate isolates from 60 patients with nosocomial infections were determined by Vitek machine.

The minimal inhibi¬tory concentration of 14 antimicrobials was determined by E-test and results were interpreted according to the Na¬tional Committee for Clinical Laboratory Standards guide¬lines.

The most common species was Pseudomonas aeruginosa.

High levels of resistance were seen to second and third generation cephalosporins, piperacillin, β-lactam / β-lactamase inhibitors combinations, and gentamicin.

The most active agents were amikacin, meropenem and imipenem (resistance 19 %, 19 %, 20 % respectively).

We conclude that second and third generation cephalospor¬ins, piperacillin, β-lactam / β-lactamase inhibitors combina¬tions and gentamicin are not suitable drugs for empirical monotherapy for aerobic Gram-negative infections in in¬tensive care units in Qatar.