Serum levels of several types of cytokines associated with chronic cholecystitis in Basrah-south of Iraq

Abstract EN

Acute cholecystits is an acute inflammation of the gallbladder.

A Total of 52 Cholecystectomy patients from a Al-Sadar Teaching hospital and 52 healthy volunteers were enrolled.

Blood specimen collected by sterile container from both.

The serum levels of pro-inflammatory cytokines (IL-1, TNF-α & IL-6) were significantly increased in gallstone patients sera comparing to healthy controls at (p < 0.05).

While anti-inflammatory cytokine IL-4 concentrations in gallstone patients sera showed significant reduced comparing to healthy controls at (p < 0.05).

And regulator cytokine IL-17 concentrations in gallstone patients sera showed not significant reduced comparing to healthy controls at (p < 0.05),.

Finally IgG concentrations in gallstone patients sera showed significant elevation comparing to healthy controls at (p < 0.05).

The elevation of pro-inflammatory cytokines including (IL-1, IL-6 & TNF-α) indicated the presence of inflammatory response associated with gallstone.

The reduction of anti-inflammatory cytokine (IL-4) and regulator cytokine (IL-17) indicated the presence of immune predisposition in patients for gallstone.