The use of topical 5-Flurouracil for primary pterygium surgery : comparison with amniotic membrane graft and conjunctival autograft

Abstract EN

To evaluate the efficacy and safety of intraoperative use of topical 5-flurouracil in primary pterygium surgery and to compare the surgical outcome with amniotic membrane graft and conjunctival autograft.

Methods: 86 eyes of 69 patients with primary pterygia were divided into 3 groups.

Group 1 was treated with pterygium excision and conjunctival autogrft.

Group 2 was treated with pterygium excision and amniotic membrane graft.

Group 3 was treated with pterygium excision and intraoperative topical 5-flurouracil.

The surgical outcome was compared in the treatment groups.

Patients were followedfor at least 6 months.

Results: The recurrence rate after conjunctival autograft, amniotic membrane graft, and topical 5-fluorouracil was2.5%, 13.5%, and 13.3% respectively.

There was no significant difference in recurrence rate among the three groups (P-0.649) There was no major complications among the three groups.

Conclusion: Conjunctival autograft, amniotic membrane graft, and topical 5-fluorouracil are equally effective in reducing the recurrence rate after primary pterygium excision.