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Immunohistochemical expression of mmp9, as a marker of local invasion in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region
Joint Authors
Ali, Thair K.
Kazim, Khitam R.
Abd Allah, Bashar H.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 27, Issue 1 (31 Mar. 2015), pp.128-132, 5 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2015-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: Malignant lymphoma is the generic term given to tumors of the lymphoid system and specifically of lymphocytes and their precursor cells, While all lymphomas are malignant neoplasms, there is a wide spectrum of clinical behavior, with some following an indolent clinical course and others behaving in an aggressive manner (will causing death in a short time frame if left untreated).
The metastatic process involves intravasation and extravasation of tumor cells, followed by reimplantation of tumor cells, formation of a new tumor stoma, Degradation of the extracellular matrix and components of the basement membrane by proteases facilitates the detachment of tumor cells, their crossing of tissue boundaries, and invasion into adjacent tissue compartments.
The importance of tumor-associated proteases in invasion and metastasis has been demonstrated for a variety of solid malignant tumors.
MMP family has been implicated in tumor cell invasion and metastasis.
Material and methods: This study included 67 formalin-fixed, paraffin-embedded histopathologically diagnosed lymphoma blocks (head and neck lesions), 24 Hodgkin’s Lymphoma and 43 Non Hodgkin’s Lymphoma.
Immunohistochemical (IHC) evaluation of MMP-9 monoclonal antibodies), in relation to the clinicopathological parameters was assessed.
Results: The mean of expression of MMP-9 in NHL was higher (65.4±18) than that in HL (56.7±21.4) though it did not reach the level of statistical difference P > (0.05), while the mean of expression of MMP-9 in relation to tumor grades was different as it had a value of (72±14.1) in low grade tumors, (68.3±15) in the intermediate grade tumor and (61.4±20.7) in high grade tumors; consequently, this difference did not reached the level of statistical significance P(ANOVA) >0.05 .
MMP 9 had no statistical significant correlation in regard to its mean in HL subtypes.
Conclusions: This study had shown that there was no significant correlation between age and mean of expression of MMP-9 in HL and NHL.
There was no statistical significant difference in the mean of expression of MMP-9 between HL and NHL subtypes.-
American Psychological Association (APA)
Ali, Thair K.& Abd Allah, Bashar H.& Kazim, Khitam R.. 2015. Immunohistochemical expression of mmp9, as a marker of local invasion in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region. Journal of Baghdad College of Dentistry،Vol. 27, no. 1, pp.128-132.
https://search.emarefa.net/detail/BIM-543437
Modern Language Association (MLA)
Ali, Thair K.…[et al.]. Immunohistochemical expression of mmp9, as a marker of local invasion in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region. Journal of Baghdad College of Dentistry Vol. 27, no. 1 (Mar. 2015), pp.128-132.
https://search.emarefa.net/detail/BIM-543437
American Medical Association (AMA)
Ali, Thair K.& Abd Allah, Bashar H.& Kazim, Khitam R.. Immunohistochemical expression of mmp9, as a marker of local invasion in hodgkin’s and non-hodgkin’s lymphoma of the head and neck region. Journal of Baghdad College of Dentistry. 2015. Vol. 27, no. 1, pp.128-132.
https://search.emarefa.net/detail/BIM-543437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 132
Record ID
BIM-543437