Borage oil rich in gamma linolenic acid (GLA)‎ reduces cardiovascular disease (CVD)‎ risk factors in hamsters fed in diet rich in saturated fatty acids (SFAS)‎ and cholesterol

Abstract EN

The experiment was applied on / 45 / healthy male of golden Syrian hamsters, were divided into three groups as follows : Control group(C), High Fat-High Cholesterol group (HF-HC) and Borage Oil group (BO).

All groups had laboratorial diet freely during / 15 / days(first period), after that each of HF-HC and BO groups took diet consisting of 80 % laboratorial diet+ 20 % fats (13.5 % sheep fat + 6.5 % coconut oil) for / 4 / weeks (second period).

The treatment of BO group changed after second period and hamsters had laboratorial diet and dosed borage oil 2g / kg of the body weight daily for / 4 / weeks (third period).

The results showed a significant increase (p = 0.0000) of the total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) concentrations approximately (163 %, 224 %, 232 %) respectively in each of HF-HC and BO groups in the second period in comparison with first period.

Our results showed, in third period, a dramatic significant decrease (P = 0.0000) in the TC, LDL-C and TG concentrations approximately (56 %, 69 %, 40 %) respectively in BO group in comparison with the same group of second period.