Rabbits' biochemical and hematological validation after the traditional use of diclofenac sodium and dexamethasone combination

Abstract EN

This study was carried out to evaluate the effect of a widely used combination in Gaza Strip, diclofenac sodium (SD) and dexamethasone (DM), at different doses on some rabbits' hematological and biochemical parameters.

Twenty two rabbits were randomly divided into 3 groups, the first one (10 rabbits) was given 1ml saline intramuscularly and kept as control.

The second group (6 rabbits) received 31doses while the third group (6 rabbits) was given 40 doses of the combination SD / DM (SD at a dose of 3 mg / kg b.wt.

i.

m.

once / day and DM at a dose of 1 mg / kg b.wt.

i.

m.

once / day for 31 days.

Administration of SD and DM for this period induced a significant decrease in Hb, RBCs, hematocrit, MCHC and platelets values and an obvious changes in the increment of WBC, MCV and MCH Values.

Moreover, there were a significant decrease in serum total protein, albumin and globulin levels, and an increase in the activities of amino transeferases (ALT), alkaline phosphatase (ALP), and serum aspartate amino transferase (AST).

In addition there were significant increment in creatinine, urea and uric acid levels and an obvious decrement in glucose, cholesterol and triacylglycerol levels.

It could be concluded that administration of SD and DM at long interval dose induced some adverse effects on hematological and biochemical parameters of liver and kidney.

That could be attributed to oxidative stress induced by the combined drugs.