Study of the toxic effect of new cadmium (ii) complex [ cdl2]. 1 2h2o on gpt and alp activity in some organs of female mice comparable with anitumor drug cyclophosphamide (cp)
Other Title(s)
دراسة التأثيرالسمي لمعقد الكادميوم ) II ( الجديد [CdL2 ] .12 H2O على فعالية انزيم GPT و ALP لدى بعض اعضاء اناث الفئران بالمقارنة مع عقار السايكلوفوسفمايد المضاد للسرطان
Author
Source
Issue
Vol. 12, Issue 1 (31 Mar. 2015), pp.140-147, 8 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2015-03-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract AR
من المعروف ان الكادميوم يضر بصحة الانسان وبشكل رئيسي من خلال تلوث مياه الشرب ، الاطعمة ، التبغ والملوثات الصناعية , الهدف من هذه الدراسة هو تقدير سمية معقد الكادميوم ) II ( الجديد : Bis[ 5-( p-nitrophenyl ) -4ˋ-phenyl-1,2.4- traizole-3-dithiocarbamato hydrazide] Cadmium (II) H ydra(0.5) ومقارنته مع عقار السايكلوفوسفامايد ) CP ( المضاد للسرطان في اناث الفئران نوع albino 0 لقد سبب هذا المعقد تغيرات في فعالية انزيمي ال GPT وال ALP في ثلاثة اعضاء بعد معاملة الحيوانات بجرع مختلفه هي ) 0.09,0.18,0.25 ( ملغم / فأر من المعقد الجديد لمدة ثلاثة ايام من خلال انخفاض غير معنوي ) 0.05 ( في فعالية انزيم GPT في الرئة ، الكبد ثم الكلية ، بينما حصلت زياده في فعالية انزيم ALP الموجود في الكلية ، الرئة و الكبد 0 الاستنتاج : بينت النتائج عدم وجود فروق معنوية ( 0.05 > P ( في فعالية انزيم GPT بين معاملة الفئران بمعقد الكادميوم ) II ( الجديد وعقار ال CP في الكبد والكلية وفعالية ALP في الكبد عند كل من الجرع الثلاث
Abstract EN
Cadmium has been known to be harmful to human healthy , manily Via contaminated drinking water , food supplies , tobacco and industrial pollutant .
The aim of this study was to determine the toxicity of new Cadmium (II) complex ( - - – – Phenyl- 1,2,4- triazole -3- dithiocarbamatohydrazide] cadmium (II) Hydra ( 0.5) and compare it with anticancer drug cyclophosphamide ( CP) in female albino mice .
This complex causes to several alterations in Enzymatic activity of Glutamate Pyruvate Transaminase (GPT) and Alkaline Phosphatase (ALP ) in three organs after the treatment of mice with different doses of a new cadmium (II) complex ( 0.09 / 0.25ml , 0.18/ 0.5ml and 0.25mg /0.7 ml /30 gm of mouse ) for three days by the decreased of Glutamate Pyruvate Transaminase activity in lung , Liver and kidney , while the Alkaline Phosphatase activity was increased in kidney , lung and liver .
The results were indicated that no significant differences ( P > 0.05 ) in Glutamate Pyruvate Transaminase activity between the treatment of mice with cadmium ( II ) complex and cyclophosphamide (CP) in the liver , kidney and Alkaline Phosphatase activity in the liver at each three doses
American Psychological Association (APA)
Abd al-Razzaq, Iman Hashim. 2015. Study of the toxic effect of new cadmium (ii) complex [ cdl2]. 1 2h2o on gpt and alp activity in some organs of female mice comparable with anitumor drug cyclophosphamide (cp). Baghdad Science Journal،Vol. 12, no. 1, pp.140-147.
https://search.emarefa.net/detail/BIM-544361
Modern Language Association (MLA)
Abd al-Razzaq, Iman Hashim. Study of the toxic effect of new cadmium (ii) complex [ cdl2]. 1 2h2o on gpt and alp activity in some organs of female mice comparable with anitumor drug cyclophosphamide (cp). Baghdad Science Journal Vol. 12, no. 1 (2015), pp.140-147.
https://search.emarefa.net/detail/BIM-544361
American Medical Association (AMA)
Abd al-Razzaq, Iman Hashim. Study of the toxic effect of new cadmium (ii) complex [ cdl2]. 1 2h2o on gpt and alp activity in some organs of female mice comparable with anitumor drug cyclophosphamide (cp). Baghdad Science Journal. 2015. Vol. 12, no. 1, pp.140-147.
https://search.emarefa.net/detail/BIM-544361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 145-147
Record ID
BIM-544361