Synthesis and characterization of some O-[2-{''2-substituted aryl (''1,''3,''4 thia diazolyl)‎ ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime derivatives

Abstract EN

In this study new derivatives of O-[2-{''2-Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime (6-11) have been synthesized from the starting material p-chloro – E- benzaldoxime 1.

Compound 2 was synthesized by the reaction of p-chloro – E- benzaldoxime with ethyl acrylate in basic medium.

Refluxing compound 2 with hydrazine hydrate in ethanol absolute afforded 3.

Derivative 4 was prepared by the reaction of 3 with carbon disulphide, treated of compound 4 with hydrazine hydrate gave 5.

The derivatives (6-11) were prepared by the reaction of 5 with different substitutes of aromatic acids.

The structures of these compounds were characterized from their melting points, infrared spectroscopy, elemental analysis and 1HNMR (some of them).

Compounds (6-11) were exhibited biological activity against E-coli bacteria.

Compound 9 exhibited higher degree of activity than the other.