The predictive value of interleukin-6, other peripheral inflammatory markers and somatosensory evoked potentials in acute ischemic stroke

Abstract EN

Objective : correlation of plasma levels of interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C- reactive protein (CRP) and somatosensory evoked potentials (SEPs) in acute ischemic stroke with stroke severity and functional outcome at 3 months.

Methodology : plasma levels of IL-6, ESR and CRP and SEPs were determined in 30 ischemic stroke patients during the first week of stroke onset and compared with 15 matched apparently healthy control subjects.

The levels of inflammatory markers and SEPs were correlated with the infarct volume, stroke severity using the Canadian Stroke Scale (CSS), and functional outcome at 3 months using the modified Rankin Score (mRS), Results: Plasma levels of IL-6, ESR and CRP were significantly higher in stroke patients than healthy controls (p < 0.001) higher in severe stroke, larger size infarctions and correlated significantly with the functional outcome at 3 months.

Also, there was significant positive correlation of N20 and P25 latency and significant negative correlation of N20 amplitude with functional outcome at 3 months.

Conclusion : the plasma levels of IL-6, ESR and CRP and the SEPs are good predictors of the functional outcome in acute ischemic stroke patients.