Effects of newcastle virus suspension on some organs ofwhite mice (balb C)‎

Abstract EN

Newcastle disease is a contagious bird disease affecting wild avian species and many domestic,it may be transmissible to humans .

Detection of Newcasstle virus confirmed by rapid test technique(Immunochromatography) .

Ten sample (10% ) out of 100 fasces samples collected from chickens were posative.

Twelve mice used in this study devided into two groups ,first group consist of six mice induced with 0.2 ml from one positive sample of Newcasttle virus suspension to evaluate some histopathological changes in liver ,lung and brain of mice,second group induced with 0.2 ml from phosphate buffer saline only.

The results revealed that histopathological changes in liver was induced using 0.2 ml of Newcasstle virus suspension ashyperpalsia in kufper cells.

Lung of mice treated with this concentration of Newcasstle virus has partialpnemonia and thickening the intra- alveolar walls.

Brain of mice treated with same concentration induced increasing in number of glial cells ( glialosis ) and apoptosis in brain cells.