Assessment of endogenous erythropoietin level in sera patients with acute ischemic stroke

Abstract EN

A stroke, is the loss of brain function due to a disturbance in the blood supply to the brain.

Ischemic type is the most common type of stroke in older adults, caused by either blockage of a blood vessel via thrombosis or arterial embolism, or by cerebral hypoperfusion.

Erythropoietin (EPO) is a glycoprotein hormone that controls erythropoiesis, or red blood cell production.

This study aimed to explore the EPO level in serum of ischemic stroke patients during the acute phase.

This study was included 40 subjects, 20 patients with acute ischemic stroke and 20 apparently healthy persons act as a control group.

Five milliliters of blood were collected in plane tube without anticoagulants for measuring EPO level in sera of patients and control by ELISA technique.

In comparison with the control group, the patients with acute ischemic stroke showed a significant increase in EPO level (P ˂ 0.002).

our data revealed that increase circulating endogenous EPO as a response to hypoxia and thereby increase oxygen supply by inducing erythropoiesis and/or other stimulatory factors that contribute the ischemic tolerance.