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Toxicity and antimicrobial activity of 6-chloro-2,4-diamino-pyrimidine
Other Title(s)
دراسة السمية و الفعالية الحيوية للمركب 6-كلورو-2 و 4-ثنائي امينو بريميدين
Joint Authors
al-Zubaydi, Adil Musa Hasan
al-Masudi, Wasfi Abbud Luaybi
Fayiz, Rana Adnan
Source
Basrah Journal of Veterinary Research
Issue
Vol. 14, Issue 1 (30 Jun. 2015), pp.105-111, 7 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
In recent years, pyrazole and pyrimidine derivatives attracted organic chemists due to their widespread potential biological and chemotherapeutic activities.
In this study, pyrimidine derivative namely 6-Chloro-2,4-diamino pyrimidine was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cerius, Streptococcus spp, Klebsella- spp and salmonella spp and fungicidal activity against Aspergillus multi, Aspergillus niger and Candida albicans.
A compound exhibited low antibacterial and antifungal activity with the reference standard Streptomycin, Vancomycin and Nystatin respectively.
The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon,s up and down method (1980).
Studied compound was found to have an LD50 of 518.6 mg / kg of body weight.
American Psychological Association (APA)
al-Masudi, Wasfi Abbud Luaybi& al-Zubaydi, Adil Musa Hasan& Fayiz, Rana Adnan. 2015. Toxicity and antimicrobial activity of 6-chloro-2,4-diamino-pyrimidine. Basrah Journal of Veterinary Research،Vol. 14, no. 1, pp.105-111.
https://search.emarefa.net/detail/BIM-556447
Modern Language Association (MLA)
al-Masudi, Wasfi Abbud Luaybi…[et al.]. Toxicity and antimicrobial activity of 6-chloro-2,4-diamino-pyrimidine. Basrah Journal of Veterinary Research Vol. 14, no. 1 (2015), pp.105-111.
https://search.emarefa.net/detail/BIM-556447
American Medical Association (AMA)
al-Masudi, Wasfi Abbud Luaybi& al-Zubaydi, Adil Musa Hasan& Fayiz, Rana Adnan. Toxicity and antimicrobial activity of 6-chloro-2,4-diamino-pyrimidine. Basrah Journal of Veterinary Research. 2015. Vol. 14, no. 1, pp.105-111.
https://search.emarefa.net/detail/BIM-556447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 110-111
Record ID
BIM-556447