Study of the role of insulin resistance as a risk factor in hcv related hepatocellular carcinoma
Joint Authors
Ibrahim, Amani Ahmad
Abd al-Alim, Mustafa Hamid
Abd Allah, Hibah Muhammad
Hilmi, Amir
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 45, Issue 1 (30 Apr. 2015), pp.107-113, 7 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Chronic HCV infection causes hepatic cirrhosis and approximately 10%-20% of cirrhotic patients may develop hepatocellular carcinoma within 5 years.
Diabetes mellitus is associated with a 2-4-fold increase in the risk of HCC.
Insulin resistance (IR) emerged as a risk factor for a variety of cancers, including endometrial and breast and various gastrointestinal cancers.
The role of IR in the development of HCC associated with chronic HCV infection has not been established.
This study elucidated the role of insulin resistance assessed by the homeostasis model (HOMA-IR) in development of hepatocellular carcinoma associated with chronic hepatitis C infection.
The study included 3 groups: GI: 100 newly diagnosed cases of HCV related hepatocellular carcinoma GII: 60 patients with HCV related chronic liver disease.
Forty healthy persons as a control group (GIII).
All groups were subjected to full history taking, physical examination, laboratory investigations abdominal ultrasonography and Triphasic C.T examination.
In addition to Calculation of Body mass Index, Measurement of fasting blood insulin and glucose, Calculation of insulin resistance using HOMA-IR.
The results showed that fasting insulin and HOMA-IR were significantly higher among HCC group than HCV group & control group.
Also, fasting insulin and HOMA-IR were significantly higher in HCV group than control group.
HOMA-IR above 3.7, insulin above 9μU/L & DM were considered independent predictors of HCC.
American Psychological Association (APA)
Ibrahim, Amani Ahmad& Abd al-Alim, Mustafa Hamid& Abd Allah, Hibah Muhammad& Hilmi, Amir. 2015. Study of the role of insulin resistance as a risk factor in hcv related hepatocellular carcinoma. Journal of the Egyptian Society of Parasitology،Vol. 45, no. 1, pp.107-113.
https://search.emarefa.net/detail/BIM-563516
Modern Language Association (MLA)
Ibrahim, Amani Ahmad…[et al.]. Study of the role of insulin resistance as a risk factor in hcv related hepatocellular carcinoma. Journal of the Egyptian Society of Parasitology Vol. 45, no. 1 (Apr. 2015), pp.107-113.
https://search.emarefa.net/detail/BIM-563516
American Medical Association (AMA)
Ibrahim, Amani Ahmad& Abd al-Alim, Mustafa Hamid& Abd Allah, Hibah Muhammad& Hilmi, Amir. Study of the role of insulin resistance as a risk factor in hcv related hepatocellular carcinoma. Journal of the Egyptian Society of Parasitology. 2015. Vol. 45, no. 1, pp.107-113.
https://search.emarefa.net/detail/BIM-563516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113
Record ID
BIM-563516