SIRT1 gene is associated with cardiovascular disease in the Iranian population
Joint Authors
Mohtavinejad, N.
Harati, H.
Poodineh, J.
Afzali, M.
Nakhaee, A.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 2 (30 Apr. 2015), pp.117-122, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Sirtuins (SIRT) have recently been identified as the pivotal regulators of lifespan and health.
SIRT1 has protective effects against cardiovascular disease (CVD) and through its deacetylase activity it regulates numerous essential pathways including regulating blood pressure, reducing atherosclerosis, heart protection against oxidative stress and inducing cardiac cell survival and growth.
Aims : Therefore, this study was conducted to evaluate whether two genetic polymorphisms of SIRT1 rs3758391 T / C and rs369274325 G / T are associated with the risk of CVD.
Material and methods: A total of 500 Iranian subjects including 250 CVD patients and 250 healthy individuals as the control group were recruited in this case–control study.
Genotyping of SIRT1 rs3758391 T / C and rs369274325 G / T polymorphisms were performed using PCR-RFLP and Tetra-ARMS PCR methods, respectively.
Results : Our findings indicated a significant difference between two groups regarding the SIRT1 rs3758391 CC genotype in both additive and recessive models.
The rs3758391 CC genotype was found to be more frequent in CVD patients than in the controls (19% vs.
6%), suggesting a statistically significant difference in either of additive (CC vs.
TT ; OR = 3.06, P = 0.001) as well as recessive models (CC vs.
TT +CT genotype; OR= 3.72, P = 0.001).
Conclusion : Our study for the first time suggests that the SIRT1 rs3758391 T / C polymorphism may confer an increased risk of CVD in both additive and recessive models, in this Iranian population.
American Psychological Association (APA)
Mohtavinejad, N.& Nakhaee, A.& Harati, H.& Poodineh, J.& Afzali, M.. 2015. SIRT1 gene is associated with cardiovascular disease in the Iranian population. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 2, pp.117-122.
https://search.emarefa.net/detail/BIM-564406
Modern Language Association (MLA)
Mohtavinejad, N.…[et al.]. SIRT1 gene is associated with cardiovascular disease in the Iranian population. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 2 (Apr. 2015), pp.117-122.
https://search.emarefa.net/detail/BIM-564406
American Medical Association (AMA)
Mohtavinejad, N.& Nakhaee, A.& Harati, H.& Poodineh, J.& Afzali, M.. SIRT1 gene is associated with cardiovascular disease in the Iranian population. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 2, pp.117-122.
https://search.emarefa.net/detail/BIM-564406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 121-122
Record ID
BIM-564406