Multidisciplinary approach for evaluation of neurocutaneous disorders in children in Sohag University Hospital, Upper Egypt
Joint Authors
Abd al-Samad, Sahar N.
Bakhit, Muhammad A.
Hassan, Ismail A. A.
Abd al-Majid, Wafa M.
Sadiq, Abd al-Rahim A.
Imam, Ahmad Muawwad
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 2 (30 Apr. 2015), pp.149-157, 9 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Neurocutaneous syndromes (NCS) are a broad term for a group of neurologic disorders that involve the nervous system and the skin.
The most common examples are neurofibromatosis type 1 (NF-1) and type 2 (NF-2), tuberous sclerosis (TS), Sturge–Weber syndrome (SWS), ataxia telangiectasia (AT), and Von Hippel Lindau disease (VHL).
These disorders are characterized clinically by neurological manifestations such as convulsions, mental retardation and learning disabilities in addition to cutaneous manifestations, and lastly tubers (benign growths found in different organs of the body).
Aim of the study : This study aimed to identify clinical, imaging, and neurophysiological profiles of neurocutaneous disorders.
Children presented to the Pediatric neurology and Dermatology clinics, Sohag University Hospital who fulfilled the criteria for diagnosis of specific neurocutaneous syndromes were eligible for this study.
Patients and methods : All studied patients were subjected to thorough clinical history, full clinical examination, developmental assessment, and dermatological examination.
Computed tomography of the brain (CT) and electroencephalography (EEG), ophthalmic, and phoniatric evaluation were also done for all children.
Echocardiography was done for only twenty children.
Results : During the period of the study we diagnosed 27 cases with neurocutaneous disorders, tuberous sclerosis represented the majority of cases as it was detected in 12 cases (44.45 %).
The main complaint was convulsions in 19 cases (70.37%), whereas skin pigmentation was detected in 18 cases (66.66 %).
Developmental assessment showed that global developmental delay was found in 20 cases (74 %).
CT of the brain showed that 15 cases (55.55%) had intracranial calcifications and abnormal EEG findings were detected in 23 cases (85.2%).
85 % of the studied children had various degrees of mental retardation.
Echocardiography showed that three cases (15 %) had ventricular wall tumor mostly rhabdomyoma.
American Psychological Association (APA)
Sadiq, Abd al-Rahim A.& Abd al-Samad, Sahar N.& Bakhit, Muhammad A.& Hassan, Ismail A. A.& Abd al-Majid, Wafa M.& Imam, Ahmad Muawwad. 2015. Multidisciplinary approach for evaluation of neurocutaneous disorders in children in Sohag University Hospital, Upper Egypt. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 2, pp.149-157.
https://search.emarefa.net/detail/BIM-564696
Modern Language Association (MLA)
Sadiq, Abd al-Rahim A.…[et al.]. Multidisciplinary approach for evaluation of neurocutaneous disorders in children in Sohag University Hospital, Upper Egypt. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 2 (Apr. 2015), pp.149-157.
https://search.emarefa.net/detail/BIM-564696
American Medical Association (AMA)
Sadiq, Abd al-Rahim A.& Abd al-Samad, Sahar N.& Bakhit, Muhammad A.& Hassan, Ismail A. A.& Abd al-Majid, Wafa M.& Imam, Ahmad Muawwad. Multidisciplinary approach for evaluation of neurocutaneous disorders in children in Sohag University Hospital, Upper Egypt. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 2, pp.149-157.
https://search.emarefa.net/detail/BIM-564696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 156-157
Record ID
BIM-564696