Anticonvulsant and anxiolytic properties of the roots of Grewia bicolor in rats
Joint Authors
Muhammad, A. H.
Shamun M. I.
al-Hadiyah T. M.
Source
Sudan Journal of Medical Sciences
Issue
Vol. 9, Issue 3 (30 Sep. 2014), pp.137-143, 7 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2014-09-30
Country of Publication
Sudan
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Grewia bicolor (G.
bicolor) root is used in traditional medicine in Sudan to treat diseases of the nervous system such as anxiety and epilepsy and also to tranquilize agitated patients.
Objectives : To explore the anticonvulsant and anxiolytic activities of this medicinal plant in rats.
Materials and Methods : The ethanolic extract of the root of G.
bicolourat (200, 400 and 800 Mg / kg, i.p was studied for its anticonvulsant effect on four in vivo rat models (Maximal Electroshock Seizure (MES), Pentylenetetrazole (PTZ)-, picrotoxin (PIC)-and Strychnine (STR)-induced seizures).
Simple activity meter was used for the evaluation of the anxiolytic properties.
Sodium valproate (400 mg kg) was used as a reference anticonvulsant drug for all models.
The protection from tonic convulsions and the number of protected animals from seizures were noted.
The numbers of movements between the squares in the activity meter were counted in the consecutive 5 minutes and the motor activity was observed.
Results : G.
bicolourroot extract showed marked anxiolytic effect and significant decrease in the motor activity (p < 0.05) since the first dose (200 mg / kg) in a dose-dependent manner.
The doses (400-800 mg / kg) of the extract significantly (p < 0.01-p < 0.001) reduced the duration of seizures induced by maximal electroshock (MES) and delayed the onset of tonic-clonic seizures produced by strychnine, whereas, all the tested doses significantly protected the animals (up to 100 %) from pentylenetetrazole-and picrotoxin-induced seizures.
Conclusion : G.
bicolourroot seemed to possess anticonvulsant and anxiolytic effect in rats.
American Psychological Association (APA)
Shamun M. I.& Muhammad, A. H.& al-Hadiyah T. M.. 2014. Anticonvulsant and anxiolytic properties of the roots of Grewia bicolor in rats. Sudan Journal of Medical Sciences،Vol. 9, no. 3, pp.137-143.
https://search.emarefa.net/detail/BIM-565338
Modern Language Association (MLA)
Shamun M. I.…[et al.]. Anticonvulsant and anxiolytic properties of the roots of Grewia bicolor in rats. Sudan Journal of Medical Sciences Vol. 9, no. 3 (Sep. 2014), pp.137-143.
https://search.emarefa.net/detail/BIM-565338
American Medical Association (AMA)
Shamun M. I.& Muhammad, A. H.& al-Hadiyah T. M.. Anticonvulsant and anxiolytic properties of the roots of Grewia bicolor in rats. Sudan Journal of Medical Sciences. 2014. Vol. 9, no. 3, pp.137-143.
https://search.emarefa.net/detail/BIM-565338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 142-143
Record ID
BIM-565338