Design, synthesis and H1-antihistaminic activity of novel 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-ones
Joint Authors
Gobinath, Manavalan
Subramanian, Natesan
Alagarsamy, Veerachamy
Source
Journal of Saudi Chemical Society
Issue
Vol. 19, Issue 3 (30 Jun. 2015), pp.282-286, 5 p.
Publisher
Publication Date
2015-06-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
In the present study a series of 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-ones were synthesized and screened for their H1-antihistaminic activity.
The synthesized compounds were characterized by IR, 1H-NMR, mass spectral data and purity of the compounds was determined by elemental analysis.
Antihistaminic activity of the title compounds was evaluated by histamine induced bronchoconstriction method in guinea pigs.
Among the series, 4-(3-chlorophenyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (S5) was the most potent with the percentage protection of 69.65 % and its potency is comparable to the reference drug chlorpheniramine maleate (70.09 % protection).
Interestingly the sedative property of compound S5 was found to be negligible (5.36 %) when compared to chlorpheniramine maleate (34.92 %).
American Psychological Association (APA)
Gobinath, Manavalan& Subramanian, Natesan& Alagarsamy, Veerachamy. 2015. Design, synthesis and H1-antihistaminic activity of novel 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-ones. Journal of Saudi Chemical Society،Vol. 19, no. 3, pp.282-286.
https://search.emarefa.net/detail/BIM-566093
Modern Language Association (MLA)
Gobinath, Manavalan…[et al.]. Design, synthesis and H1-antihistaminic activity of novel 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-ones. Journal of Saudi Chemical Society Vol. 19, no. 3 (2015), pp.282-286.
https://search.emarefa.net/detail/BIM-566093
American Medical Association (AMA)
Gobinath, Manavalan& Subramanian, Natesan& Alagarsamy, Veerachamy. Design, synthesis and H1-antihistaminic activity of novel 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-ones. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 3, pp.282-286.
https://search.emarefa.net/detail/BIM-566093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 286
Record ID
BIM-566093