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The role of tumor necrosis factor alpha and its soluble receptors in infection complicating acute leukaemia
Other Title(s)
دور عامل التحلل الأورام TNF ألفا و مستقبلاته الذئبة بالبلازما في عدوى ميكروبية عند مرضى سرطان الدم الميلودي الحادي
Joint Authors
Kamil, Nifin Abd al-Munim Hasan
Mustafa, Ahmad Kamil
al-Bih, Isam Abd al-Munim Sadiq
Ahmad, Suhayr Muhammad
Mustafa, Iman Mukhtar Suwayfi
Ahmad, Yusriyah Abd al-Rahman
Mahmud, Husam Kamal
Abd al-Nasir, Mahir Abd al-Jabir
Source
Issue
Vol. 26, Issue 3 (31 Jul. 2002), pp.73-86, 14 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2002-07-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract EN
Septic shock is the major cause of death in patients with acute myeloid leukaemia (AML).
Cytokines especially TNF-a and others are implicated in the severe problems associated with septic shock causing the activation of the pro-inflammatory mediators.
Aim: This study was designed to examine the changes that occur in the levels of TNF-a and its soluble receptors in infection in patients with AML and the changes that occur in these parameters during the neutropenic state.
Patients: Forty-seven patients of newly diagnosed AML (With age range 12-60 years) as well as twenty-five age and sex-matched healthy subjects were included in this study.
Results, patients group was subdivided into 4 subgroups according to the presence or absence of fever and neutropenia.
Patients who were febrile and non neutropenic showed statistically significant rise in TNF-a level compared to control (P< 0.001) also TNF-RI and TNF-RI1 were significantly higher than controls (P< 0.001).
The same results were obtained with the febrile, non neutropenic andfebrile, neutropenic patients.
The febrile, neutropenic patients haVE a mild but significant elevation of sTNF-PJ and sTBF-RIl when compared to control (P< 0.05).
Patients with mild sepsis showed significant (P< 0.01) elevation in TNF-a only.
Patients with severe sepsis showed significant elevation in sTNFR-1.
sTNFR-11 (P< 0.05) for each.
Patients with septic shock showed significant elevation in TNF-a, sTNFR-1andsTNFR-11(P<0.05) for each.
All groups of sepsis were compared with afebrile, neutropenic patients.
Conclusion: The levels of soluble receptors of TNF-a in the serum may reflect the inflammatory status better than TNF-a levels and the rise in their levels iS correlated with the severity of sepsis
American Psychological Association (APA)
Ahmad, Suhayr Muhammad& Ahmad, Yusriyah Abd al-Rahman& Mustafa, Ahmad Kamil& al-Bih, Isam Abd al-Munim Sadiq& Mahmud, Husam Kamal& Mustafa, Iman Mukhtar Suwayfi…[et al.]. 2002. The role of tumor necrosis factor alpha and its soluble receptors in infection complicating acute leukaemia. Assiut Medical Journal،Vol. 26, no. 3, pp.73-86.
https://search.emarefa.net/detail/BIM-56643
Modern Language Association (MLA)
Ahmad, Suhayr Muhammad…[et al.]. The role of tumor necrosis factor alpha and its soluble receptors in infection complicating acute leukaemia. Assiut Medical Journal Vol.26, No.3(July, 2002), pp.73-86.
https://search.emarefa.net/detail/BIM-56643
American Medical Association (AMA)
Ahmad, Suhayr Muhammad& Ahmad, Yusriyah Abd al-Rahman& Mustafa, Ahmad Kamil& al-Bih, Isam Abd al-Munim Sadiq& Mahmud, Husam Kamal& Mustafa, Iman Mukhtar Suwayfi…[et al.]. The role of tumor necrosis factor alpha and its soluble receptors in infection complicating acute leukaemia. Assiut Medical Journal. 2002. Vol. 26, no. 3, pp.73-86.
https://search.emarefa.net/detail/BIM-56643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 84-86
Record ID
BIM-56643