Renal failure in patients with multiple myeloma
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 3 (31 May. 2015), pp.482-488, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-05-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Renal dysfunction is encountered in 20-25 % of patients with multiple myeloma (MM) at the time of diagnosis.
There is often a precipitating event.
Several biochemical and clinical correlations with renal failure in MM have been reported.
Renal failure in MM is associated with worse outcome of the disease.
We retrospectively analyzed the medical records of 64 patients with MM admitted to our institution during the period January 1992 to December 2012.
Abnormal renal function was observed in 24 (37.5 %) patients and 17 (26.6 %) of them had renal failure ; 14 of the 17 (82.4 %) of patients with renal failure had Stage III MM.
Urine Bence-Jones protein was positive in ten (58.8 %) patients with renal failure versus ten (21.3 %) patients without renal failure (P = 0.004).
Potential precipitating factors of renal failure were determined in nine patients.
Renal function normalized in 11 patients with simple measures, while six patients required hemodialysis; one remained dialysis dependent till time of death.
Early mortality occurred in five (29.4 %) patients with renal failure as compared with two (4.3 %) patients in the group without renal failure (P = 0.005).
In conclusion, renal failure is associated with a higher tumor burden and Bence-Jones proteinuria in patients with MM.
It is reversible in the majority of patients ; however, early mortality tends to be higher in patients with persistent renal failure.
American Psychological Association (APA)
Almueilo, Samir H.. 2015. Renal failure in patients with multiple myeloma. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 3, pp.482-488.
https://search.emarefa.net/detail/BIM-567557
Modern Language Association (MLA)
Almueilo, Samir H.. Renal failure in patients with multiple myeloma. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 3 (May. 2015), pp.482-488.
https://search.emarefa.net/detail/BIM-567557
American Medical Association (AMA)
Almueilo, Samir H.. Renal failure in patients with multiple myeloma. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 3, pp.482-488.
https://search.emarefa.net/detail/BIM-567557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 486-488
Record ID
BIM-567557