Tumor necrosis factor gene expression in regular hemodialysis patients
Joint Authors
al-Haddad, Himmat E.
Mari, Muhammad A.
Sami, Tariq M.
Farid, Rim Jan
Sharaf al-Din, Usamah A.
Sharif, Mayy
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 3 (31 May. 2015), pp.460-467, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-05-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
This study evaluates tumor necrosis factor (TNF)-alfa gene expression in patients with end-stage renal disease (ESRD) on regular hemodialysis as an expression of cardiovascular disease (CVD) risk even on a sub-clinical level and its relation to some of the parameters incriminated in the pathogenesis and the establishment of uremic arteriopathy.
A total of 51 patients with ESRD on regular hemodialysis and 20 healthy subjects matching in age and gender as a control group were recruited.
All selected cases were subjected to serum lipid profile, Creactive protein (CRP), TNF-alfa gene expression and Doppler study of carotid arteries to estimate carotid intimal media thickness (cIMT).
Serum triglycerides (TGS) level (P < 0.001), CRP positivity (P = 0.002), relative quantification (RQ) of TNF-alfa gene expression (P = 0.007) and cIMT (P = 0.02) were significantly higher while high-density lipoprotein (HDL) level (P < 0.001) was significantly lower among cases compared with controls.
RQ showed a significant positive correlation with CRP titer (rho = 0.583, P = 0.011).
Results also showed a significant strong negative correlation between with CRP titer and cIMT (rho = -0.590, P = 0.010).
CRP titer showed only a significant strong negative correlation with age (rho = -0.589, P = 0.01) and positive correlation with HDL (rho = 0.51, P = 0.031).
Patients with ESRD have increased gene expression of TNF-alfa and CRP titer together with increased atherosclerosis as expressed by increased cIMT.
American Psychological Association (APA)
al-Haddad, Himmat E.& Mari, Muhammad A.& Sami, Tariq M.& Farid, Rim Jan& Sharif, Mayy& Sharaf al-Din, Usamah A.. 2015. Tumor necrosis factor gene expression in regular hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 3, pp.460-467.
https://search.emarefa.net/detail/BIM-567611
Modern Language Association (MLA)
Sharaf al-Din, Usamah A.…[et al.]. Tumor necrosis factor gene expression in regular hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 3 (May. 2015), pp.460-467.
https://search.emarefa.net/detail/BIM-567611
American Medical Association (AMA)
al-Haddad, Himmat E.& Mari, Muhammad A.& Sami, Tariq M.& Farid, Rim Jan& Sharif, Mayy& Sharaf al-Din, Usamah A.. Tumor necrosis factor gene expression in regular hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 3, pp.460-467.
https://search.emarefa.net/detail/BIM-567611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 466-467
Record ID
BIM-567611