Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population
Joint Authors
Khan, Umran Ali
Shaik, Nur Ahmad
Pasupuleti, Nagarjuna
Chava, Srinivas
Jahan, Parveen
Hasan, Qurratulain
Rao, Pragna
Source
Saudi Journal of Biological Sciences
Issue
Vol. 22, Issue 3 (30 Sep. 2015), pp.243-248, 6 p.
Publisher
Publication Date
2015-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
In this study we scrutinized the association between the A8344G / A3243G mutations and a 9-bp deletion polymorphism with gestational diabetes mellitus (GDM) in an Asian Indian population.
The A3243G mutation in the mitochondrial tRNALeu (UUR) causes mitochondrial encephalopathy myopathy, lactic acidosis, and stroke-like episodes (MELAS), while the A8344G mutation in tRNALys causes myoclonus epilepsy with ragged red fibers (MERRF).
We screened 140 pregnant women diagnosed with GDM and 140 non-GDM participants for these mutations by PCR-RFLP analysis.
Both A3243G and A8344G were associated with GDM (A3243 : OR-3.667, 95 % CI = 1.001–13.43, p = 0.03 ; A8344G : OR-11.00, 95 % CI = 0.6026–200.8, p = 0.04).
Mitochondrial DNA mutations contribute to the development of GDM.
Our results conclude that mitochondrial mutations are associated with the GDM women in our population.
Thus it is important to screen other mitochondrial mutations in the GDM women.
American Psychological Association (APA)
Khan, Umran Ali& Shaik, Nur Ahmad& Pasupuleti, Nagarjuna& Chava, Srinivas& Jahan, Parveen& Hasan, Qurratulain…[et al.]. 2015. Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population. Saudi Journal of Biological Sciences،Vol. 22, no. 3, pp.243-248.
https://search.emarefa.net/detail/BIM-567667
Modern Language Association (MLA)
Khan, Umran Ali…[et al.]. Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population. Saudi Journal of Biological Sciences Vol. 22, no. 3 (2015), pp.243-248.
https://search.emarefa.net/detail/BIM-567667
American Medical Association (AMA)
Khan, Umran Ali& Shaik, Nur Ahmad& Pasupuleti, Nagarjuna& Chava, Srinivas& Jahan, Parveen& Hasan, Qurratulain…[et al.]. Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 3, pp.243-248.
https://search.emarefa.net/detail/BIM-567667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 247-248
Record ID
BIM-567667