Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria
Joint Authors
Buqari, Dina T.
al-Faraj, Shadha
Arafah, Maria
al-Awdah, Nurah
al-Khayri, Khalid S.
al-Suhaybani, Ahmad
al-Sad, Khalid O.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 3 (31 May. 2015), pp.572-579, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-05-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
- Patients
- Bone marrow
- Kidneys
- Diseases
- Toxicology
- Kidney failure
- Interstitial nephritis
- Glomerulonephritis
- Paroxysmal nocturnal hemoglobinuria
Abstract EN
Paroxysmal nocturnal hemoglobinuria is a rare disease of the red blood cell membrane that renders it lyzable by the complement system, leading to chronic intravascular hemolysis.
Renal hemosiderosis is a well-known complication of intravascular hemolytic anemia and can lead to acute kidney injury and renal failure.
The use of herbal medicine is common worldwide.
The nephrotoxicity of herbal remedies can take several forms, which include acute kidney injury and acute and chronic interstitial nephritis.
In addition, the use of herbal remedies can result in bone marrow toxicity and suppression.
C1q nephropathy is an uncommon form of glomerular disease characterized by dominant or co-dominant glomerular immunofluorescence positivity for C1q in the absence of clinical and serological evidence of systemic lupus erythematosus, and has various clinical presentations and outcome.
Here, we report a patient of undiagnosed paroxysmal nocturnal hemoglobinuria who consumed herbal medicine of unknown constituents and clinically presented with anemia and acute kidney injury.
The pathological findings of bone marrow and renal biopsies that include bone marrow intoxication, severe renal hemosiderosis and acute interstitial nephritis and kidney injury, as well as co-dominant glomerular deposition of C1q, are discussed.
In addition, we discuss and hypothesize the possible pathogenesis of glomerular C1q deposition in the setting of paroxysmal nocturnal hemoglobulinuria.
American Psychological Association (APA)
Buqari, Dina T.& al-Faraj, Shadha& Arafah, Maria& al-Awdah, Nurah& al-Khayri, Khalid S.& al-Suhaybani, Ahmad…[et al.]. 2015. Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 3, pp.572-579.
https://search.emarefa.net/detail/BIM-567851
Modern Language Association (MLA)
Buqari, Dina T.…[et al.]. Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 3 (May. 2015), pp.572-579.
https://search.emarefa.net/detail/BIM-567851
American Medical Association (AMA)
Buqari, Dina T.& al-Faraj, Shadha& Arafah, Maria& al-Awdah, Nurah& al-Khayri, Khalid S.& al-Suhaybani, Ahmad…[et al.]. Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 3, pp.572-579.
https://search.emarefa.net/detail/BIM-567851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 578-579
Record ID
BIM-567851