Holocord low grade astrocytoma-role of radical irradiation and chemotherapy
Joint Authors
Goyal, Shikha
Julka, P. K.
Puri, Tarun
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 27, Issue 2 (30 Jun. 2015), pp.105-108, 4 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Topics
Abstract EN
Spinal intradural tumors, especially those extending along the entire length of the spinal cord, termed as ‘holocord’ tumors are uncommon.
Most of these are gliomas, with astrocytomas (low grade) predominating in children and ependymomas in adults.
Other histologies, though reported, are even rarer.
Management is debatable, with both surgery and radiotherapy of such extensive tumors posing challenges.
We describe a case of a 14-year-old girl with holocord astrocytoma extending from cervicomedullary junction till lumbar spine, who recovered full neurological function following radical irradiation of entire spine followed by temozolomide-based chemotherapy.
No grade 3 / 4 bone marrow morbidity was seen.
Five years following treatment, she maintained normal neurological function and apparently normal pubertal and skeletal growth despite residual disease visible on imaging.
Literature review of existing reports of holocord astrocytomas highlighting management and outcome is presented.
ª 2015 The Authors.
Production and hosting by Elsevier B.
V.
on behalf of National Cancer Institute
American Psychological Association (APA)
Goyal, Shikha& Puri, Tarun& Julka, P. K.. 2015. Holocord low grade astrocytoma-role of radical irradiation and chemotherapy. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 2, pp.105-108.
https://search.emarefa.net/detail/BIM-568340
Modern Language Association (MLA)
Goyal, Shikha…[et al.]. Holocord low grade astrocytoma-role of radical irradiation and chemotherapy. Journal of the Egyptian National Cancer Institute Vol. 27, no. 2 (Jun. 2015), pp.105-108.
https://search.emarefa.net/detail/BIM-568340
American Medical Association (AMA)
Goyal, Shikha& Puri, Tarun& Julka, P. K.. Holocord low grade astrocytoma-role of radical irradiation and chemotherapy. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 2, pp.105-108.
https://search.emarefa.net/detail/BIM-568340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 107-108
Record ID
BIM-568340