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Exosomal protein interactors as emerging therapeutic targets in urothelial bladder cancer
Joint Authors
Kumari, Nitu
Saxena, Sunita
Agrawal, Usha
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 27, Issue 2 (30 Jun. 2015), pp.51-58, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background : Exosomes are rich sources of biological material (proteins and nucleic acids) secreted by both tumor and normal cells, and found in urine of urinary bladder cancer patients.
Objective : The objective of the study was to identify interacting exosomal proteins in bladder cancer for future use in targeted therapy.
Methods : The Exocarta database (www.exocarta.org) was mined for urinary bladder cancer specific exosomal proteins.
The urinary bladder cancer specific exosomal proteins (n = 248) were analyzed to identify enriched pathways by Onto-tool Pathway Express (http : / / vortex.cs.wayne.edu / ontoexpress).
Results : Enriched pathways included cellular architecture, motility, cell to cell adhesion, tumorigenesis and metastasis.
Proteins in the 9 top-ranked pathways included CTNNA1 (alpha-catenin), CTNNB1 (beta-catenin), VSAP, ITGA4, PAK1, DDR1, CDC42, RHOA, NRAS, RHO, PIK3AR1, MLC1, MMRN1, and CTTNBP2 and network analysis revealed 10 important hub proteins and identified inferred interactor NF2.
Conclusions: The importance of identifying interactors is that that they can be used as targets for therapy, for example, using Bevacizumab (avastin-an angiogenesis inhibitor) against NF2 to inhibit protein-protein interactions will inhibit tumor growth and progression by hindering the exosome biogenesis.
ª 2015 Production and hosting by Elsevier B.
V.
on behalf of National Cancer Institute, Cairo University.
This is an open access article under the CC BY-NC-ND license
American Psychological Association (APA)
Kumari, Nitu& Saxena, Sunita& Agrawal, Usha. 2015. Exosomal protein interactors as emerging therapeutic targets in urothelial bladder cancer. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 2, pp.51-58.
https://search.emarefa.net/detail/BIM-568376
Modern Language Association (MLA)
Kumari, Nitu…[et al.]. Exosomal protein interactors as emerging therapeutic targets in urothelial bladder cancer. Journal of the Egyptian National Cancer Institute Vol. 27, no. 2 (Jun. 2015), pp.51-58.
https://search.emarefa.net/detail/BIM-568376
American Medical Association (AMA)
Kumari, Nitu& Saxena, Sunita& Agrawal, Usha. Exosomal protein interactors as emerging therapeutic targets in urothelial bladder cancer. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 2, pp.51-58.
https://search.emarefa.net/detail/BIM-568376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 57-58
Record ID
BIM-568376