Effects of interleukin-10 gene polymorphism on clinical diversity and activity of systemic lupus erythematosus
Joint Authors
Amayirah, Ahmad A.
Muhammad, Kamal F.
al-Badawi, Nisrin E.
Rashad, Mayy H.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 42, Issue 2 (30 Jun. 2015), pp.49-54, 6 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim This study was carried out to determine the effects of interleukin (IL)-10 gene polymorphism 1082A/G on clinical diversity and activity of systemic lupus erythematosus (SLE), as it was shown to be associated with E26 transcription factor binding site, and to assess IL-10 concentration in SLE patients.
Patients and methods Blood was drawn from 54 SLE patients and 27 healthy controls for DNA extraction.
The single nucleotide polymorphism was identified using the PCR-restriction fragment length polymorphism, and serum sample was collected to assay IL-10 concentration.
Results There was an increase in IL-10 concentration in SLE total patients (mean 49.5 pg/ml).
Mutant allele A (76.9%) was found more frequently in SLE patients compared with allele G (23.1%).
Genotype AA (66.7%) was found more frequently, followed by AG (20.4%) and GG (12.9%).
Conclusion IL-10 concentration was elevated in SLE patients and was shown to be associated with disease activity.
IL-10 gene polymorphism is not a strong indicator to show susceptibility of the disease.
American Psychological Association (APA)
Amayirah, Ahmad A.& Muhammad, Kamal F.& al-Badawi, Nisrin E.& Rashad, Mayy H.. 2015. Effects of interleukin-10 gene polymorphism on clinical diversity and activity of systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation،Vol. 42, no. 2, pp.49-54.
https://search.emarefa.net/detail/BIM-574204
Modern Language Association (MLA)
Amayirah, Ahmad A.…[et al.]. Effects of interleukin-10 gene polymorphism on clinical diversity and activity of systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation Vol. 43, no. 2 (2015), pp.49-54.
https://search.emarefa.net/detail/BIM-574204
American Medical Association (AMA)
Amayirah, Ahmad A.& Muhammad, Kamal F.& al-Badawi, Nisrin E.& Rashad, Mayy H.. Effects of interleukin-10 gene polymorphism on clinical diversity and activity of systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation. 2015. Vol. 42, no. 2, pp.49-54.
https://search.emarefa.net/detail/BIM-574204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 53-54
Record ID
BIM-574204