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Upper extremity subclinical autonomic and peripheral neuropathy in systemic lupus erythematosus
Joint Authors
al-Badawi, Muhjah A.
Fath Allah, Mahmud M.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 42, Issue 2 (30 Jun. 2015), pp.87-93, 7 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background Systemic lupus erythematosus (SLE) is an autoimmune, multiorgan disease that affects connective tissues of many organs or systems, including the nervous system, where it affects the autonomic, the peripheral, and the central nervous system.
Objective The aim of this study was to investigate the association of subclinical autonomic and peripheral neuropathy with SLE and to correlate neurophysiological parameters with clinical and laboratory data.
Patients and methods Fifty-six SLE patients were included in this study.
In addition, thirty age-matched and sexmatched healthy participants served as a control group.
Exclusion criteria included patients having symptoms or signs indicating autonomic dysfunction or peripheral neuropathy.
Also, endocrinal, toxic, compression, and traumatic neuropathies were excluded.
Patients were assessed clinically and by laboratory investigations.
Neurophysiological assessment included sympathetic skin response of the median nerve including latency and amplitude.
In addition, nerve conduction study of both median and ulnar nerves was performed including motor distal latency, amplitude, nerve conduction velocity, and distal sensory latency.
Results Pure sensory abnormality was detected in one patient, whereas pure motor neuropathy was found in 19 patients.
Mixed sensory–motor abnormalities were detected in two patients.
Sympathetic skin response was not elicited in 13 patients, whereas latency and amplitude abnormalities were detected in 11/43 and 9/43 patients, respectively.
Sympathetic and axonal neuropathy was not correlated with the disease duration or the disease activity.
Conclusion The pattern of neuropathy in SLE is mainly axonal.
Also, the sympathetic nervous system is affected in lupus patients with a rate of up to 40% of the cases
American Psychological Association (APA)
Fath Allah, Mahmud M.& al-Badawi, Muhjah A.. 2015. Upper extremity subclinical autonomic and peripheral neuropathy in systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation،Vol. 42, no. 2, pp.87-93.
https://search.emarefa.net/detail/BIM-574217
Modern Language Association (MLA)
Fath Allah, Mahmud M.& al-Badawi, Muhjah A.. Upper extremity subclinical autonomic and peripheral neuropathy in systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation Vol. 43, no. 2 (2015), pp.87-93.
https://search.emarefa.net/detail/BIM-574217
American Medical Association (AMA)
Fath Allah, Mahmud M.& al-Badawi, Muhjah A.. Upper extremity subclinical autonomic and peripheral neuropathy in systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation. 2015. Vol. 42, no. 2, pp.87-93.
https://search.emarefa.net/detail/BIM-574217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 93
Record ID
BIM-574217