Assessment of bone remodeling in renal osteodystrophy by non-invasive methods

Abstract EN

Metobolic bine disease might commmci' carfy In the of renal failure This study therefore examined relative efficacy certain non -invasive techniques to diagnose renal bone disease in chromic renal failure patients, by measuring bone specific alkaline phosphates (bAP) type I procollagen C-terminal extension propertied OF type I collagen (PICP), iwertenkin-6 (IL-6).

fj: micro globulin ) (faKf) and bone mineral density measurements, in addition to intact parathyroid hormone, total serum calcium and inorgattie phosphorus determinations.

This study was conducted on sixty nine patients 0} males and 18 females) with chronic renal failure and 15 healthy subjects I JO males and 5 females) as control group (group I)..

According to the management of chronic renal failure, the patients were divided into two groups: 16 patient on conservative treatment (group 11).

53 patients on hem dialysis (croup 111) [3? patients with disease duration up to 5 year (group IlIa), 16 patients with disease duration > 5years (group lllB ) Serum level of intact parathyroid hormone (iPTHi revealed significant elevation in all patient groups compared to controls and also in group Mb compared to group* Ilia a<}d l Serum levels of bone specific alkaline phosphates (b/.PJ.

procollagen type i (PlCP).

Interleukin -6 (7IL -6) AND b2 microgiobuLin} (B2M) revealed significant elevation in all diseased patient groups in comparison to controls.

BAP showed significant elevation In group ll\h compared to groups II and Ilia.

P/CP showed significant elevation in group Ilia compared to group II.

While mean values of IL-6 and H M ahawci significant elevation in liemoduilysif groups tlila, Illb) comparedto group on conservative treatment (group II).

Regarding bone mineral density and T-score, statistically insignificant redaction was detected in all diseased patient groups compared to controls, except group Ilia thtU showed significant reduction in T-score compared to controls