Cholesterol of normal immature neutrophils : comparison with acute myeloblastic leukemia cells and normal neutrophiIs
Joint Authors
Muhammad, S. M.
Sami K. M. Marco H.
Tompson K. P.
Source
Sudan Medical Laboratory Journal
Issue
Vol. 1, Issue 1 (30 Jun. 2011), pp.19-24, 6 p.
Publisher
Omdurman Islamic University Faculty of Medical Laboratory
Publication Date
2011-06-30
Country of Publication
Sudan
No. of Pages
6
Main Subjects
Topics
Abstract EN
-The lipid composition of immature myeloid cells from the bone marrow of normal persons and myeloblasts from patients with acute myeloblastic leukemia was studied and compared with the lipid composition of normal mature human neutrophils.
Total cholesterol, phospholipid, and fatty acid composition was determined on each cell type.
The leukemic cells showed decreased total cholesterol and cholesterol-to-phospholipid ratio, increased phosphatidylcholine and phosphatidylinositol, decreased phosphatidylethanolamine, and an increased percentage of unsaturated fatty acids when compared to normal mature neutrophils.
A nearly identical pattern was seen in the normal immature myeloid precursors from normal bone marrow.
We conclude that the altered lipid composition of acute myeloblastic leukemia cells is related to unexplained factors related to cell age and not to malignancy per se.-Klock, J.
C., and J.
K.
Pieprzyk.
Cholesterol, phospholipids, and fatty acids of normal immature neutrophils: comparison with acute myeloblastic leukemia cells and normal neutrophils.
J.
Lzptd Res.
1979.
20: 908-91
American Psychological Association (APA)
Sami K. M. Marco H.& Muhammad, S. M.& Tompson K. P.. 2011. Cholesterol of normal immature neutrophils : comparison with acute myeloblastic leukemia cells and normal neutrophiIs. Sudan Medical Laboratory Journal،Vol. 1, no. 1, pp.19-24.
https://search.emarefa.net/detail/BIM-576017
Modern Language Association (MLA)
Sami K. M. Marco H.…[et al.]. Cholesterol of normal immature neutrophils : comparison with acute myeloblastic leukemia cells and normal neutrophiIs. Sudan Medical Laboratory Journal Vol. 1, no. 1 (2011), pp.19-24.
https://search.emarefa.net/detail/BIM-576017
American Medical Association (AMA)
Sami K. M. Marco H.& Muhammad, S. M.& Tompson K. P.. Cholesterol of normal immature neutrophils : comparison with acute myeloblastic leukemia cells and normal neutrophiIs. Sudan Medical Laboratory Journal. 2011. Vol. 1, no. 1, pp.19-24.
https://search.emarefa.net/detail/BIM-576017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 24
Record ID
BIM-576017