Oral toxicity of agro-fungicides : tilt (propiconazole)‎, milcurb super (ethirimol)‎ and their mixture to nubian goats

Abstract EN

Propiconazole and Ethimirol are triazole fungicides of many cereals, fruits and vegetables.

They have been registered in Sudan since 1980s.

Human in Sudan continuously receives these fungicides via food.

Propiconazole has a potential for carcinogenicity in rodents.

A set of experiments were designed to detect their toxicity in experimental goats.

Five minutes post-dosing, the groups of animals dosed orally with Propiconazole (100mg / kg / day), Ethirimol (100mg / kg / day) and their mixture (50 : 50 mg / kg / day) showed some clinical signs which recovered after 4 hours.

Death occurred in days 11-25 in animals dosed with the mixture.

The most prominent feature in postmortem lesions in poisoned animals was the congestion in different body organs.

Histopathological changes were the fatty change of liver and kidneys.

The digestive tract was inflamed while the heart was flabby as the some alveoli contained RBCs, acidophilic albuminous exudate and lymphocytes.

In Ethirimol dosed group the values of PCV, Hb and MCHC decreased significantly (p < 0.

001).

The serum urea concentration, GOT activity and urea values were high (p < 0.

001) in both of them.

Animals dosed with mixture had significantly (p < 0.

05 - 0.

001) higher PCV, MCV, MCH and WBC than the control.

Significantly high values of serum urea concentration (p < 0.

01) and GOT activity (p < 0.

001) were reported in goats dosed with the mixture.

Low values in concentration of total protein (p < 0.

01), Mg (p < 0.

001) and K (p < 0.

001) were reported compared to control group.

The present study on fungicides toxicity to Nubian goats has shown that the clinical, pathological, biochemical and haematological data are indicative of effects on the central nervous system, liver, kidney, heart, lungs and gastrointestinal tract.