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Study of hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract on hyperglycemic glucose induced rats
Joint Authors
Izz al-Din, O. M.
al-Imam, A.
al-Hajj, Yusra
al-Rahman Fath, Shiraz
Gharib Ala, Samah
al-Sadiq, Tamadiur
Abd al-Karim, Hind
Ahmad, M. A.
Source
Sudan Medical Laboratory Journal
Issue
Vol. 1, Issue 2 (31 Dec. 2011), pp.43-48, 6 p.
Publisher
Omdurman Islamic University Faculty of Medical Laboratory
Publication Date
2011-12-31
Country of Publication
Sudan
No. of Pages
6
Main Subjects
Topics
Abstract EN
This experiment was conducted to study the hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract (outer external layer) in hyperglycemic rats induced by injection of glucose at the rate of 2g / kg body weight, after fasting 18 hours.
According to our experiment rats weighing 80-120g were used for this study.
Rats were divided into 5 groups (n = 6).
Group I was injected 10 mg/kg body weight of glibenclamide (Daonil), this is the standard group.
Group II left as control and treated with 10 mg / kg distilled water, group III was treated with 200 mg/kg body weight and group IV was treated with 400 mg/kg of ethanolic grape fruit extract.
The last group (group V) was treated with 800 mg/kg of the extract.
The rats in the standard group have low concentration of blood glucose after 2 hrs, 4 hrs (86.
3-76.
8 mg / dl respectively).
Group III (200 mg / kg extract) have blood glucose level of 121.
8 and 124.
2 mg/dl respectively.
Group IV (400 mg / kg) have blood glucose 147.
2 and 135.
7 mg / dl respectively, while the rats in last group (800 mg/kg) have the lowest level of blood glucose 90.8 and 103 mg/dl respectively which was the best group, and the blood glucose was nearly similar to that of the standard
American Psychological Association (APA)
Izz al-Din, O. M.& al-Imam, A.& Ahmad, M. A.& al-Hajj, Yusra& al-Rahman Fath, Shiraz& Gharib Ala, Samah…[et al.]. 2011. Study of hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract on hyperglycemic glucose induced rats. Sudan Medical Laboratory Journal،Vol. 1, no. 2, pp.43-48.
https://search.emarefa.net/detail/BIM-576246
Modern Language Association (MLA)
Izz al-Din, O. M.…[et al.]. Study of hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract on hyperglycemic glucose induced rats. Sudan Medical Laboratory Journal Vol. 1, no. 2 (2011), pp.43-48.
https://search.emarefa.net/detail/BIM-576246
American Medical Association (AMA)
Izz al-Din, O. M.& al-Imam, A.& Ahmad, M. A.& al-Hajj, Yusra& al-Rahman Fath, Shiraz& Gharib Ala, Samah…[et al.]. Study of hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract on hyperglycemic glucose induced rats. Sudan Medical Laboratory Journal. 2011. Vol. 1, no. 2, pp.43-48.
https://search.emarefa.net/detail/BIM-576246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 48
Record ID
BIM-576246