The effects of passive cigarette smoking on the respiratory system among the healthy wives of active smokers

Abstract EN

Smokers no! only increase their own risk of pulmonary diseases, but also contribute to the health fiAfc of non-smokers through the production of smoke.

Evidence continues to build regarding the positive association between passive smoking and increased risk of respiratory symptoms and lung diseases.

The aim of this study is to assess the effect of passive smoking on pulmonary ventilation and serum lipid peroxides levels.

The use of urinary antiserum coiinine as cheap blomarkers to evaluate the degree of exposure to smoke •*as aim evaluated.

The studied population included $0 adult healthy volunteers: 20 currently smokers, 20 wives of active smokers spouse (passive smokers) and the remaining 10 are non-sttiokers control.

Ventilatory pulmonary Junction tests {FVC% predicted, FFVl/hVC ratio, b'liVl *Apredicted andh'Eb 25-75% predicted) were made to all subjects.

Urinary cotinine.

serum cotinine and lipid peroxides levels were assessed USING spectrophotonuitnc method.

We found that urinary and serum cotinine and lipid peroxide were increased significantly in pass** (P<00QJ, P

P* 0.01 andP '0.00 J) respectively than controls.

Serum cotinine and lipid peroxides were elevated significantly (P<0.05) in active smokers compared to passive-smoker* A significant dose response relationship between smirking index and serum M urinary cotinine and lipid peroxides was found except for urinary counine where M significant correlation could he observed upon exposure to mild smoke and in mildly active smokers.

A definite reduction in pulmonary function indices (FEI '1% predicted FFYL'Flu ratio and FEF2.S-75% predicted} was found in passive smokers, meanwhile FVCH predicted did not sh

FEF°75- predicted and FEV \'1l% predicted) and smoking index' lipid peroxides and urinary and serum cotinine showed a clear relationship between them m bath passive and active smokers Meanwhile, W/'W ratio showed significant negathn) correlation with smoking index and urinary cotinine and insignificant correlation with strut* lipid peroxides and serum cotinine.

Our data demonstrated that passive smokers are at risk to develop subsequent destructive lung disease which was evident by increase in the level vj lipid peroxides (marker of oxidative stress) and decline in sptromithc indices (specially decline in Fli\'l% predictive, which is the most strangle predictive index of chronic ? obstructive lung disease* in adults).

The decline in FFF2S-?5% predictive indicates tnt possibility of smalt airway diseases Hie benefit of use of urinary and serum cotinine at cheap hioniarlars of exposure to cigarette smoke Is clarified.