Programmed necrosis-mediated cell death and disease : recent advances

Abstract EN

Cell death classification has been based on morphological characteristics for decades.

Modern advances in molecular technology enabled us to explore cell death pathways on a level of unprec-edented detail.

While necrosis has been considered a negative unpreventable form of cell death, recent findings demonstrate that a subtype of necrosis, namely necroptosis, is a regulated pro-grammed process.

Hence, therapeutic intervention to inhibit necroptosis-mediated loss of cells in a disease process is possible.

This review highlights recent advances in programmed necrosis (necroptosis) and its potential relationship to human disease.