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Serum level of beta 2 microglobulin in end stage renal disease patients with pruritus
Joint Authors
Rashad, Haydi S.
Atwah, Muna A.
Hassan, Basmah B.
Tawfiq, Jamal A.
Muhammad, Rushdi W.
Source
Suez Canal University Medical Journal
Issue
Vol. 17, Issue 2 (31 Dec. 2014), pp.86-92, 7 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Etiology of uremic pruritus as a common complication in patients with end stage re-nal disease (ESRD) is not fully understood.
Aim: Our aim was to highlight beta 2 microglobulin (β2M) as a risk factor for uremic pruritus and to assess the diagnostic performance of β2M for predicting pruritus in patients with ESRD.
We assessed the serum level of β2M in hemodialysis patients with pruritus compared to those without pruritus.
Subjects and Methods: This study in-cluded 17 ESRD patients on hemodialysis with pruritus and 17 ESRD patients on hemodialysis without pruritus.
Patients included in this study were subjected to detailed history taking, as-sessment of pruritus severity using visual analog scale (VAS) in pruritic group, kidney function test and estimation of serum β2M levels.
Results: The pre-dialysis serum level of β2M was signifi-cantly higher in pruritic group than in nonpruritic group (2.79±1.20 and 1.52±0.66, respectively, p=0.002).
The post-dialysis serum level of β2M was also significantly higher in pruritic group than in nonpruritic group (3.44±1.31 and 1.89±0.62 respectively, p=0.001).
The diagnostic performance of β2M for predicting pruritus in patients with ESRD was good as evidenced by area under the curve (AUC: 81.7, p=0.0001).
Best cut off point for predicting pruritus in ESRD was >2.05 in pre-dialysis and >2.66 in post-dialysis.
Conclusion: Our results showed high serum level of β2M in ESRD patients with pruritus that may highlight the role of β2M in the pathogenesis of this important problem.
β2M has good diagnostic performance of for predicting pruritus in patients with ESRD.
American Psychological Association (APA)
Rashad, Haydi S.& Atwah, Muna A.& Hassan, Basmah B.& Muhammad, Rushdi W.& Tawfiq, Jamal A.. 2014. Serum level of beta 2 microglobulin in end stage renal disease patients with pruritus. Suez Canal University Medical Journal،Vol. 17, no. 2, pp.86-92.
https://search.emarefa.net/detail/BIM-577002
Modern Language Association (MLA)
Rashad, Haydi S.…[et al.]. Serum level of beta 2 microglobulin in end stage renal disease patients with pruritus. Suez Canal University Medical Journal Vol. 17, no. 2 (Dec. 2014), pp.86-92.
https://search.emarefa.net/detail/BIM-577002
American Medical Association (AMA)
Rashad, Haydi S.& Atwah, Muna A.& Hassan, Basmah B.& Muhammad, Rushdi W.& Tawfiq, Jamal A.. Serum level of beta 2 microglobulin in end stage renal disease patients with pruritus. Suez Canal University Medical Journal. 2014. Vol. 17, no. 2, pp.86-92.
https://search.emarefa.net/detail/BIM-577002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 91-92
Record ID
BIM-577002