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BRAF gene : from human cancers to developmental syndromes
Joint Authors
Muhammad, Husayn Shaykh Ali
al-Haqq, Zahir
Hoessli, Daniel C.
Khogeer, Ghaidaa Siraj
al-Sayyid, Ranim Radwan
Husayn, Muhammad Ramadan Manwar
al-Aama, Jumana Yousuf
Baig, Mukhtiar
Source
Saudi Journal of Biological Sciences
Issue
Vol. 22, Issue 4 (31 Dec. 2015), pp.359-373, 15 p.
Publisher
Publication Date
2015-12-31
Country of Publication
Saudi Arabia
No. of Pages
15
Main Subjects
Topics
Abstract EN
The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies).
The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes––Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
ª 2014 Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
American Psychological Association (APA)
Husayn, Muhammad Ramadan Manwar& Baig, Mukhtiar& Muhammad, Husayn Shaykh Ali& al-Haqq, Zahir& Hoessli, Daniel C.& Khogeer, Ghaidaa Siraj…[et al.]. 2015. BRAF gene : from human cancers to developmental syndromes. Saudi Journal of Biological Sciences،Vol. 22, no. 4, pp.359-373.
https://search.emarefa.net/detail/BIM-577402
Modern Language Association (MLA)
Baig, Mukhtiar…[et al.]. BRAF gene : from human cancers to developmental syndromes. Saudi Journal of Biological Sciences Vol. 22, no. 4 (2015), pp.359-373.
https://search.emarefa.net/detail/BIM-577402
American Medical Association (AMA)
Husayn, Muhammad Ramadan Manwar& Baig, Mukhtiar& Muhammad, Husayn Shaykh Ali& al-Haqq, Zahir& Hoessli, Daniel C.& Khogeer, Ghaidaa Siraj…[et al.]. BRAF gene : from human cancers to developmental syndromes. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 4, pp.359-373.
https://search.emarefa.net/detail/BIM-577402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 369-373
Record ID
BIM-577402