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Anti-urolithiatic and anti-oxidant effects of fenugreek on ethylene glycol-induced kidney calculi in rats
Joint Authors
Shaykhah, Mazhar S.
Ismail, Trifa F.
Aziz, Falah M.
Source
Jordan Journal of Biological Sciences
Issue
Vol. 8, Issue 2 (30 Jun. 2015), pp.159-163, 5 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2015-06-30
Country of Publication
Jordan
No. of Pages
5
Main Subjects
Topics
Abstract EN
Renal calculi formation is one of the most common urological disorders.
Urinary stone disease is a common disease which affects 10-12 % of the population in industrialized countries.
The objective of the present study is to investigate the antiurolithiatic and antioxidant activity of fenugreek on ethylene glycol-induced urolithiasis in rats.
Twenty male rats weighing 203-263 were used for this study.
Group A animals received distilled water for 28 days.
Group B to group D animals received 1% v/v ethylene glycol in distilled water for 28 days.
Groups C and D received cystone and fenugreek, respectively, from day 15 to day 28.
On day 28, blood was collected for serum malondialdehyde (MDA) and calcium level monitoring.
Kidneys of rats from all the groups were removed, and histopathologically examined using Paraffin method.
Samples of kidney were viewed under a scanning electron microscope.
Histologically, the kidney of fenugreek treated group appeared mostly to be calculi-free, even better than the cystone treated group.
Similarly, the calcium oxalate deposits, the serum (MDA), the renal tissue calcium content were all significantly lower than those in the other groups.
The results of the present study suggest that fenugreek has a strong antiurolithiatic and antioxidant activity
American Psychological Association (APA)
Shaykhah, Mazhar S.& Ismail, Trifa F.& Aziz, Falah M.. 2015. Anti-urolithiatic and anti-oxidant effects of fenugreek on ethylene glycol-induced kidney calculi in rats. Jordan Journal of Biological Sciences،Vol. 8, no. 2, pp.159-163.
https://search.emarefa.net/detail/BIM-577409
Modern Language Association (MLA)
Shaykhah, Mazhar S.…[et al.]. Anti-urolithiatic and anti-oxidant effects of fenugreek on ethylene glycol-induced kidney calculi in rats. Jordan Journal of Biological Sciences Vol. 8, no. 2 (Jun. 2015), pp.159-163.
https://search.emarefa.net/detail/BIM-577409
American Medical Association (AMA)
Shaykhah, Mazhar S.& Ismail, Trifa F.& Aziz, Falah M.. Anti-urolithiatic and anti-oxidant effects of fenugreek on ethylene glycol-induced kidney calculi in rats. Jordan Journal of Biological Sciences. 2015. Vol. 8, no. 2, pp.159-163.
https://search.emarefa.net/detail/BIM-577409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 162-163
Record ID
BIM-577409