Induction chemotherapy followed by concurrent chemoradiotherapy in the management of locally advanced cancer larynx

Abstract EN

Recent development in improving disease control, survival and functional outcome in patient with locally advanced cancer larynx has focused upon combining radiotherapy with chemotherapy.

Recent trials with induction chemotherapy followed by concurrent chemoradiotherapy were made aiming to cytoreduce gross disease.

Permit organ preservation and eliminate distant microscopic disease.

Also to improve loco regional disease control over that achievable with radiotherapy clone.

The objective of this study was to detrmine the efficiency and toxicity of neoadjuvant chemotherapy followed by concurrent chemaradiotherapy The study included 24 patients.

They received 3 cycles of platinol..

leucoverin and 5.flurouracil followed by concurrent chemoradiothcrapy using cisplantin 20 mg/m2 weekly.

After induction therapy only 2 patients showed complete clinical response while 18 patients showed partial response 4 remained with progressive disease.

After completion of chemoradlotherapy (17/20) 85% of patients showed complete remission clinically, endoscopically, and by histopathological study white 4 patients showed partial response and underwent palliative laryngectomy .

Conclusion: The addition of concomitant chemorathotherapy to induction chemotherapy for locoregionally advanced laryngeal cancer appears to Increase locaregional control and organ preservation over conventional therapy.