Allelic prevalence of intron 3 insertiondeletion genetic polymorphism of dna double-strand break repair gene XRCC4 in four healthy Iranian populations
Joint Authors
Abarghouei, Layla Falah Zadah
Zahidi, Tahira
Mirabedi, Farkhonde
Sadat, Mustafa
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 3 (30 Sep. 2015), pp.215-218, 4 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Topics
Abstract EN
The X-ray cross-complementing group 4 (XRCC4; OMIM: 194363), plays an important role in repair of DNA double-strand breaks via non-homologous end joining pathway.
In order to find the allelic prevalence of an insertion/deletion polymorphism in intron 3 of XRCC4 (Ins/Del; rs28360071) among Iranian populations, the present study was carried out.
Subjects and methods: The total study subjects consisted of 662, 200, 291, and 200 individuals from Shiraz (Fars province; belong to Persians), Abarku (Yazd province; belong to Persians), Tabriz (East Azerbaijan province; belong to Azaris), and Yasuj (Kohgiluyeh va Boyer-Ahmad province; belong to Lurs), respectively.
Genotypic analysis of the Ins/Del XRCC4 polymorphism was detected by the PCR method.
Results: The prevalence of the Del allele in Shiraz, Abarku, Tabriz, and Yasuj was estimated 44.4%, 37.3%, 53.6% and 45.0%, respectively.
Tabriz (Azaris) showed the significant difference with other populations (v2 =20.06, df = 1, P <0.001).
Also there was a significant difference between Persians of Shiraz and Abarku (v2 =6.43, df = 1, P= 0.011).
Conclusion: Although there is a significant heterogeneity between Iranian populations, the Del allele shows high prevalence among Iranian populations, which is much higher than the allelic prevalence among Asians.
American Psychological Association (APA)
Abarghouei, Layla Falah Zadah& Zahidi, Tahira& Mirabedi, Farkhonde& Sadat, Mustafa. 2015. Allelic prevalence of intron 3 insertiondeletion genetic polymorphism of dna double-strand break repair gene XRCC4 in four healthy Iranian populations. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 3, pp.215-218.
https://search.emarefa.net/detail/BIM-578073
Modern Language Association (MLA)
Abarghouei, Layla Falah Zadah…[et al.]. Allelic prevalence of intron 3 insertiondeletion genetic polymorphism of dna double-strand break repair gene XRCC4 in four healthy Iranian populations. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 3 ( 2015), pp.215-218.
https://search.emarefa.net/detail/BIM-578073
American Medical Association (AMA)
Abarghouei, Layla Falah Zadah& Zahidi, Tahira& Mirabedi, Farkhonde& Sadat, Mustafa. Allelic prevalence of intron 3 insertiondeletion genetic polymorphism of dna double-strand break repair gene XRCC4 in four healthy Iranian populations. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 3, pp.215-218.
https://search.emarefa.net/detail/BIM-578073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 217-218
Record ID
BIM-578073