Contrasting genetic influence of PON 1 coding gene polymorphisms L55M and Q192R on individuals’ response to environmental agents
Joint Authors
Mursi, Nadiyah Yusuf Sadiq
al-Misri, Muhyi Qadri
Kamal, Maha Mustafa
Jalal, Sarah Yaqut
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 3 (30 Sep. 2015), pp.233-237, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Paraoxonase (PON1) is an A-esterase capable of hydrolyzing the active metabolites (oxons) of many organophosphorus (OP) insecticides.
Human PON1 displays two polymorphisms in the coding region (Q192R and L55M) and several polymorphisms in the promoter and the 30-UTR regions.
Animal studies have shown that PON1 is an important determinant of OP toxicity though a direct satisfactory verification in humans is still lacking.
Aim: To investigate the impact of polymorphisms in the PON1 coding region (Q192R and L55M) on individual sensitivity to OP poisoning.
Subjects and methods: This study enrolled 42 subjects (21 females and 21 males, age range 1.5– 53 years) diagnosed of acute OP poisoning.
They were classified into 4 grades according to manifestations.
All subjects were genotyped for the PON1 gene polymorphisms; Q192R and L55M using RFLP-PCR, then genotype frequencies were compared between different OP grades.
Results: Genotype frequency distribution of PON1 L55M polymorphism among different OP poisoning grades revealed no significant difference (p>0.05) between the four grades.
In contrast, frequency distribution of PON1 Q192R polymorphism showed a highly significant (p< 0.001) difference between different grades of OP poisoning, with QQ genotype predominating in grade 4 with a frequency of 66.7%, followed by QR genotype (33.3%), while the RR and QR genotypes were similarly distributed in grade 1 with a frequency of 50% for each.
Conclusion: The current results suggest a possible association between QQ genotype and poor OP poisoning prognosis.
American Psychological Association (APA)
Mursi, Nadiyah Yusuf Sadiq& al-Misri, Muhyi Qadri& Kamal, Maha Mustafa& Jalal, Sarah Yaqut. 2015. Contrasting genetic influence of PON 1 coding gene polymorphisms L55M and Q192R on individuals’ response to environmental agents. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 3, pp.233-237.
https://search.emarefa.net/detail/BIM-578236
Modern Language Association (MLA)
Mursi, Nadiyah Yusuf Sadiq…[et al.]. Contrasting genetic influence of PON 1 coding gene polymorphisms L55M and Q192R on individuals’ response to environmental agents. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 3 ( 2015), pp.233-237.
https://search.emarefa.net/detail/BIM-578236
American Medical Association (AMA)
Mursi, Nadiyah Yusuf Sadiq& al-Misri, Muhyi Qadri& Kamal, Maha Mustafa& Jalal, Sarah Yaqut. Contrasting genetic influence of PON 1 coding gene polymorphisms L55M and Q192R on individuals’ response to environmental agents. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 3, pp.233-237.
https://search.emarefa.net/detail/BIM-578236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 237
Record ID
BIM-578236