Efficacy of atorvastatin in treatment of Iraqi obese patients with hypercholesterolemia
Joint Authors
Farhan, Hasan A.
Khazal, Faris A.
Mahmud, Insaf J.
al-Rabii, Abd al-Hadi
al-Qurashi, Muthanna
Hajji, Ghazi F.
Abd al-Rahim, Yusuf
al-Musawi, Ali M.
Source
al-Kindy College Medical Journal
Issue
Vol. 10, Issue 2 (31 Dec. 2014), pp.61-67, 7 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : dyslipidemia plays a crucial rule in the development of cardiovascular disease, which has become the leading cause of death in most developed countries as well as in developing countries (1).
The effects of reducing low density lipoprotein-C (LDL-C) concentrations on the prevention of cardiovascular events and stroke have been well reported in many clinical trials.
urea, creatinine, uric acid or glucose with any dose.
Conclusion : Short-term atorvastatin therapy in dyslipidemic obese patients caused a reduction of TC, TG, LDL, and VLDL, but had no significant effect on HDL, non-significant changes in blood urea, serum creatinine, serum uric acid or blood glucose, while there was a dose dependent elevation of ALT and AST.
Objectives : Evidence supports the use of statins for lipid modifications in the primary prevention of coronary artery disease, morbidity and mortality.
This study aims to determine the effectiveness of atorvastatin in treating dyslipidemia in Iraqi obese patients.
Methods : 200 overweight and obese patients with hypercholesterolemia, according to NCEP ATP III criteria, were included.
They were randomized into 3 groups according to atorvastatin dose, 10, 20, 40 mg/ day, and treated for 8 weeks.
Blood lipid profile, liver enzymes ALT and AST, urea, creatinine, uric acid, calcium and glucose were measured before and after therapy.
Results : There was a significant reduction of total cholesterol (TC), Triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), but a non-significant reduction of high density lipoprotein (HDL) with all atorvastatin doses.
The high doses of the drug caused a significant elevation of serum levels of ALT and AST and a significant decrease of blood calcium ; but there was no significant change in blood levels of
American Psychological Association (APA)
Farhan, Hasan A.& Khazal, Faris A.& Mahmud, Insaf J.& Hajji, Ghazi F.& al-Rabii, Abd al-Hadi& al-Qurashi, Muthanna…[et al.]. 2014. Efficacy of atorvastatin in treatment of Iraqi obese patients with hypercholesterolemia. al-Kindy College Medical Journal،Vol. 10, no. 2, pp.61-67.
https://search.emarefa.net/detail/BIM-580858
Modern Language Association (MLA)
Farhan, Hasan A.…[et al.]. Efficacy of atorvastatin in treatment of Iraqi obese patients with hypercholesterolemia. al-Kindy College Medical Journal Vol. 10, no. 2 (2014), pp.61-67.
https://search.emarefa.net/detail/BIM-580858
American Medical Association (AMA)
Farhan, Hasan A.& Khazal, Faris A.& Mahmud, Insaf J.& Hajji, Ghazi F.& al-Rabii, Abd al-Hadi& al-Qurashi, Muthanna…[et al.]. Efficacy of atorvastatin in treatment of Iraqi obese patients with hypercholesterolemia. al-Kindy College Medical Journal. 2014. Vol. 10, no. 2, pp.61-67.
https://search.emarefa.net/detail/BIM-580858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 66-67
Record ID
BIM-580858