Study of osteopontin in diabetic patients as indicator for myocardial infarction

Abstract EN

This study included (180) human samplest (89 males, 91 females), classified into 4 groups : (49) diabetic patients (21 males, 28females) were attended to the diabetic and endocrinology center at Al-Sader medical city in Al-Najaf Al-Ashraf, and registered in the center as type 2 diabetic mellitus patients (DM) group.

(40) patients (23 males, 17 females) attended to the coronary care unit (CCU) at Al-Sader medical city in Al-Najaf Al-Ashraf and diagnosed as having myocardial infarction (they all showed S-T elevation) (MI) group.

(46) patients (21 males, 25 females) attended to the coronary care unit (CCU) at Al-Sader medical city in Al-Najaf Al-Ashraf and diagnosed as having myocardial infarction (they all showed S-T elevation), and previously diagnosed as type 2 diabetic patients (DMMI) group.

(45) healthy subjects (24 males, 21 females)vas (control) group.

all patients and control subjects were aged between 40-75 years.

All of them were non obese (Body Mass Index < 30).Samples collected during the period from May 2011 till February 2012.

The measured parameters include: fasting blood sugar (FBS), glycosylated haemoglobin (HbA1c %), lipid profile (LDL, TG, HDL, vLDL, atherogenic Index), serum Osteoppontin (OPN).

The results showed a significant increase (P < 0.05) in FBS of DM and DMMI groups.

A significant increase (P < 0.05) in the percentage of HbA1c in all patients (DM, MI, and DMMI groups) compared with the control.

Lipid profile parameters and atherogenic index were significantly (P<0.05) higher in all patients than healthy individual.

Levels of serum OPN increased in all patients significantly in comparing with the control group.

MI group was higher significantly than DM group.

No significant difference in serum OPN found between males and females.

According to age range, there is a significant increase in OPN levels in all patients in the age range (40-50) when compared with control subjectsgroup in this age range, but OPN levels didn’t differ significantly among study groups aged 51-60 years.

In elderly (>60 years) MI patients showed significant high levels of OPN in comparison with elderly DM patients.

In conclusion, serum OPN levels were higher in MI patients and in diabetic patients suffering from myocardial infarction, so this parameter could be a risk marker for MI in diabetic patients