Study of some serological tests on patients with visceral leishmaniasis

Abstract EN

This study aimed to measure the alterations in serum zinc (Zn) and acute phase proteins ( C-reactive protein and Ceruloplasmin) concentrations in patients with visceral leishmaniasis (VL).

A total of 62 individuals were enrolled in this study : 52 individuals were infected with visceral leishmaniasis and 10 individuals as healthy control.

Serum zinc levels were significantly (p < 0.

05) decreased in patient group(76.

25 ± 4.

59 μg / dl ) when compared with healthy control (103.

75 ± 3.

77 μg / dl ) .

C-reactive protein , as a mediator of innate immunity, removed damaged cells by activating the classical complement pathway revealed elevated levels in patients (4.

36 ± 0.

23mg / l ) when compared with the healthy control (2.

50 ± 0.

28mg / l ).

The level of Ceruloplasmin was also significantly (p < 0.

05) increased in VL patients (0.82±0.05 mg/dl) as compred with healthy subjects (0.

43 ± 0.

03mg / dl).

These results showed that serum essential trace elements Zn, C-reactive protein and ceruloplasmin concentrations have been changed in VL patients.

This may be a part of defense strategies of organism.