Study off the biochemical association of selenium with glutathione peroxidase enzyme as antioxidants in patients with kidney stone

Abstract EN

The current study included 104 patients (males and females) with kidney stone , they were diagnosed in lithotripsy unit in Basra General Hospital, their mean ages were 40 14 and 70 apparently healthy control, their mean ages 38 12, classified according to age, sex, smoking and family history.

The study has evaluated the levels of selenium and the activity of glutathione peroxidase enzyme in patients with kidney stone and healthy as controls.

The results showed a highly significant decrease (P < 0.01) in selenium level and glutathione peroxidase activity in patients as compared to control.

In accordance with age, smoking and family history there was a significant decrease (P < 0.01), and there was a significant decrease in males as compared to females.

These results explain, the effect of oxidative stress in increasing injury of kidney stone, through the decrease of the antioxidants (selenium and glutathione peroxidase enzyme) in patients with kidney stone.