Gram negative bacterial complications in acute lymphpblastic leukemiapatients in Erbil City

Abstract EN

Fifty eight Acute Lymphpblastic Leukemia( ALL ) patients were recorded when they admitted to the Nanacally Hospital for Blood Diseases in Erbil and submitted to treatment with first induction phase therapy.

(40childern 69% and 18 adults-31%) between December 2012 and November 2013.The study were determine the type, frequency and severity of gram negative bacterial infections.

A total of 74 isolates were isolated and identified by VITEK 2 GN Colorimetric Identification Card.

Abscess swab was the most common site of infection 30/74(40%) followed by oral and throat swab19/74 (26%), urine14 /74(19%).

The detection of gram negative bacterial in the patient’s, blood has diagnostic by ( automated blood culture <020 )instrument for incubation and periodic reading which were positive in 11/74(15%).

Bone marrow(BM) was negative ( 0%)isolate.

The most gram negative was E.

coli 24/74 (32%) ,Pseudomonas aeruginosa 16/74(22%)) Kebsiella pneumoniae ,8/74(11%) Acinetobacr baumannii 6/74(8% ) Proteus mirabilis, Raoultella ornithinolytica and Yersinia enterocolitica 4/74(5%) Serratia fonticola, Pseudomonas luteola, Acinetobacter genomospecies3,and Morganella morganii 2/74(3%) of isolates .

MIC of 17 antimicrobial were tested and there was variation in the resistance of the isolates .E.coli isolates were resistance to 71% of the antibacterial K.pneumonia to 53% .S.

fonticola to 35% P.

aeruginosa to 41% P.

luteola to 6% ,A.genomospecies3 to 23.5% A.

baumannii to 70.5% .

P.mirabilis to 35%, R.ornithinolytica to 82%.M.

morganii to 76% , Y.

enterocolitica to 41% of the antibacterial.

All isolates were susceptible to Imipenem and Meropenem.The subtypes of ALL were 39(67%)L1,19(33%)L2,L3(0%) .Only 52/58 (90%)were associated with neutropenia and 6/58(10%) were without neutropenia.

The male patients were (55%) and female were (45%) ,(71%)B cell and (29%) were T cell ALL .

Half of the patients had no any education levels 50%, patients who had no family history 71% and 88%of patients were no smoking .