Role of tumor necrosis factor-alpha, lipid peroxidation, nitric oxide and cyclic gaunosine monophosphate in lung cancer

Abstract EN

Cytokines and lipid peroxidation can participate in the complicated process of carcinogenesis and tumor progression.

In the.

Present study, serum levels tumor Necrosis factor- alplta (TNF-a).

Lipid peroxides (LPO).

Nitric oxide (NO) and cyclic gaunvsine monophosphate (cGMP) were measured m 32 patient? With lung cancer and in 30 healthy control subjects The levels of TNF-a and cGMP were measured using ELISA and the levels of LPO and WRE measured using calonmctric methods.

The levels of TNF -a LPO.

NO and cGMP were significantly higher in higher in lung cancer patients Than In control t-group In patients with lung cancer, a significant positive correlation was found between LPO and each of TNF-a and NO According to the clinical stage and histological type , the serum levels of TNF-a.

LPO and NO were significantly elevated in he advanced stage and nont small cell lung cancer compared with the limited Sung cancer and small cell cancer groups respectively.

The serum levels of cGMP were higher in advanced than limited lung cancer A significant positive correlation between NO and cGMP was found in patients with advanced lung cancer In cone-fusion, the elevation of serum levels of TNF a.

IPO and NO in patients with lung cancer may hove prognostic value being associated with a worse prognosis .

the NO/cGMP system may play on important role in the advanced lung cancer