The effect of magnesium sulphate on lidocaine epidural analgesia in goats

Abstract EN

Five adult baladi goats were used to evaluate the effect of different doses of magnesium sulphate (MgSo4) that were injected epidurally in combination with lidocaine Hcl 2 % on the duration and area of analgesia as well as side effects.

Animals were treated as follow: treatment I was injected with lidocaine Hcl 2% (1 ml/7 kg).

Treatments II, III and IV were injected with lidocaine Hcl 2 % (1 ml / 7 kg) in combination with 25, 50 and 100 mg MgSo4 10 %, respectively.

Results revealed that onset of analgesia was delayed in treatments II, III and IV (3, 3.

5 and 3.5 minute, respectively).

Treatment IV produced the longest duration of analgesia (99.

80 ± 2.

35 min).

There was a significant increase in the animal recumbency in treatment I as compared to other treatments.

The extent of analgesic area was almost the same in all treatments that extended from perineum to T13.

Ataxic effect recorded in different patterns in treated animals.

Treatment I had the longest duration of recumbency followed by mild ataxia in treatment II.

In other treatments, ataxia was not developed.

In conclusion, the combination of 2 % lidocaine with 100 mg MgSo410 % injected epidurally in goats resulted in prolonged duration of analgesia extending from the perineum to the flank region without ataxia, cardiovascular or respiratory side effects.